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Cat. No.: HY-P99893

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Biologically Validated

Rozibafusp alfa

Name: Rozibafusp alfa
Brand: MedChemExpress
SKU: HY-P99893
Price: 650.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: AMG 570)

Customer Review

Based on 1 Customer Validation

Rozibafusp alfa (AMG-570) is a humanized IgG2-κ monoclonal antibody targets ICOSL and BAFF. Rozibafusp alfa can be used for the research of systemic lupus erythematosus and other autoimmune diseases.

For research use only. We do not sell to patients.

Purity : 96.98%
CAS No.: 2143449-47-0
Molecular Weight:158.123 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rozibafusp alfa Chemical Structure

CAS No.: 2143449-47-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

Human IgG2 kappa

Recommend Isotype Controls

Human IgG2 kappa, Isotype Control

Species Reactivity

Human

All TNF Receptor Isoforms :

In Vivo

Rozibafusp alfa shows more efficacious effects than single ICOSL or BAFF inhibitor in mouse NZB/NZW lupus model and collagen induced arthritis (CIA) models^[1].
Rozibafusp alfa reduces B cell in cynomolgus monkeys, same as the pharmacological effect of BAFF inhibition^[1].
1.19 Pharmacokinetic Properties of Rozibafusp alfa in Cynomolgus Monkeys^[1].

	Cynomolgus Monkeys IV 10 mg/kg	Cynomolgus Monkeys SC 10 mg/kg
C_max (μg/mL)	264	112
T_max (hr)		72
AUC_0-inf (μg•hr/mL)	26100	23800
MRT_0-inf (hr)	138	144
CL (mL/hr/kg)	0.388	0.427
Vss (mL/kg)	52.1

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

23308 [NCBI]

Accession

O75144

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG2 kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized B7-H2/ICOSLG Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78075) can bind Rozibafusp alfa. The EC₅₀ for this effect is 12.53 ng/mL.

Chemical Information

CAS No. 2143449-47-0
Appearance Liquid
Molecular Weight 158.123 kDa
Color Colorless to light yellow
SMILES

[Rozibafusp alfa]
Synonyms

AMG 570
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Zhang M, et al. Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment. Clin Exp Rheumatol. 2019 Nov-Dec;37(6):906-914. [Content Brief]

[2]. Rozibafusp alfa. IMGT.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Purity & Documentation
References

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MCE Japan Authorized Agent:

Product Name:
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Rozibafusp alfa

Bradford Protein Assay Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

Protein A Agarose

DPBS Buffer (1×)

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

All TNF Receptor Isoforms