Ruxolitinib impurity-1
Based on 1 Customer Validation
Ruxolitinib impurity-1 is a pyrrolopyrimidine derivative and also an impurity of Ruxolitinib (HY-50856). Ruxolitinib serves as a synthetic intermediate for TDM-180967, a dual JAK1/Tyk2 inhibitor, and can also be used as an impurity reference standard for drug quality control.
For research use only. We do not sell to patients.
- Purity : 99.77%
- CAS No.: 952518-97-7
- Formula: C9H7N5
- Molecular Weight:185.19
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 952518-97-7
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Appearance Solid
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Molecular Weight 185.19
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Formula C9H7N5
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Color White to off-white
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SMILES
N1C=C(C=N1)C1=NC=NC2=C1C=CN2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 10 mg/mL (54.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.3999 mL | 26.9993 mL | 53.9986 mL | 134.9965 mL |
| 5 mM | 1.0800 mL | 5.3999 mL | 10.7997 mL | 26.9993 mL | |
| 10 mM | 0.5400 mL | 2.6999 mL | 5.3999 mL | 13.4996 mL | |
| 15 mM | 0.3600 mL | 1.8000 mL | 3.5999 mL | 8.9998 mL | |
| 20 mM | 0.2700 mL | 1.3500 mL | 2.6999 mL | 6.7498 mL | |
| 25 mM | 0.2160 mL | 1.0800 mL | 2.1599 mL | 5.3999 mL | |
| 30 mM | 0.1800 mL | 0.9000 mL | 1.8000 mL | 4.4999 mL | |
| 40 mM | 0.1350 mL | 0.6750 mL | 1.3500 mL | 3.3749 mL | |
| 50 mM | 0.1080 mL | 0.5400 mL | 1.0800 mL | 2.6999 mL |
Ruxolitinib impurity-1 Related Classifications
HY-W059210 Related Classifications
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