Cat. No.: HY-W010736

1,2-Dipalmitoyl-sn-glycerol

Name: 1,2-Dipalmitoyl-sn-glycerol
Brand: MedChemExpress
SKU: HY-W010736
Price: 30.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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1,2-Dipalmitoyl-sn-glycerol is a diacylglycerol that activates PKC. 1,2-Dipalmitoyl-sn-glycerol promotes GLUT4 translocation to the cell surface and recruitment to the plasma membrane of adipocytes. 1,2-Dipalmitoyl-sn-glycerol can be used in research on type 2 diabetes.

For research use only. We do not sell to patients.

Purity : 98.0%
CAS No.: 30334-71-5
Formula: C₃₅H₆₈O₅
Molecular Weight:568.92

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

1,2-Dipalmitoyl-sn-glycerol Chemical Structure

CAS No.: 30334-71-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]^[2]^[3]^[4]^[5]^[6]^[7]

PKC-α

PKC-βI

PKC-βII

PKC-γ

PKC-δ

PKC-ε

GLUT4

All PKC Isoforms :

All GLUT Isoforms :

In Vitro

Carbohydrate MetabolismBacterial InfectionOthers

Carbohydrate Metabolism

DP-DAG (30 μM; 20 min) promotes GLUT4 translocation to the cell surface in 3T3L1-GLUT4myc adipocytes^[1].
1,2-Dipalmitoyl-sn-glycerol (30 μM; 10 min) does not activate Akt in 3T3L1-GLUT4myc adipocytes^[1].

Bacterial Infection

1,2-Dipalmitoyl-sn-glycerol (1.0 μM) alone supports optimal balanced growth of Frankia strain BR^[5].

Others

1,2-Dipalmitoyl-sn-glycerol (100 μM; 5 min) activates PKCα, -βI, -βII, -γ, -δ, and -ε, but not PKCλ/ι or -ζ, in cell-free systems^[1].
1,2-Dipalmitoyl-sn-glycerol (0.1-10.0 μg/mL; 24 h) does not alter cell proliferation in normal human dermal fibroblasts in vitro at doses up to 10.0 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

3T3L1-GLUT4myc adipocytes
Concentration:

30 μM
Incubation Time:

20 min
Result:

Increased GLUT4 localization on the cell surface.

Western Blot Analysis^[1]

Cell Line:

3T3L1-GLUT4myc adipocytes
Concentration:

30 μM
Incubation Time:

10 min
Result:

Did not enhance phosphorylation of Akt at Thr308 and Ser473.

Cell Proliferation Assay^[2]

Cell Line:

Normal human dermal fibroblasts from neonatal foreskin
Concentration:

0.1 μg/mL; 1.0 μg/mL; 10.0 μg/mL
Incubation Time:

24 h
Result:

Induced no treatment-related changes in fibroblast proliferation as determined by DNA synthesis.

In Vivo

Topically applied 1,2-dipalmitoyl-sn-glycerol (diC₁₆) (50 mg/mL; topical; twice daily; 5 days) does not induce a significant change in skin pigmentation in guinea pigs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Guinea pigs (outbred, pigmented, 12-20 weeks old)^[2]
Dosage:

50 mg/mL
Administration:

topical; twice daily; 5 days
Result:

Induced no significant change in skin pigmentation.
Caused no erythema at treated sites.
Showed a complete lack of increased pigmentation.

Related Protocols :

Chemical Information

CAS No. 30334-71-5
Appearance Solid
Molecular Weight 568.92
Formula C₃₅H₆₈O₅
Color White to off-white
SMILES

OC[C@H](OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : 5.56 mg/mL (9.77 mM; ultrasonic and warming and heat to 60°C)

DMSO : 2 mg/mL (3.52 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7577 mL

8.7886 mL

17.5772 mL

5 mM

0.3515 mL

1.7577 mL

3.5154 mL

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tsuchiya A, et al. Diacylglycerol promotes GLUT4 translocation to the cell surface in a PKCε-dependent and PKCλ/ι and -ζ-independent manner. Life sciences. 2013 Aug 14;93(5-6):240-6.

[2]. Slaga TJ. Safety Assessment of Glyceryl Diesters as Used in Cosmetics.

[3]. Guzmán E. Effect of the incorporation of nanosized titanium dioxide on the interfacial properties of 1, 2-dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir monolayers. Langmuir. 2017 Oct 10;33(40):10715-25.

[4]. Nishida Y, et al. Remarkable functions of -3 hydroxy and phosphocholine groups in 1,2-diacyl--glycerolipids to induce clockwise (+)-helicity around the 1,2-diacyl moiety: Evidence from conformation analysis by H NMR spectroscopy. Beilstein journal of organic chemistry. 2017;13:1999-2009.

[5]. Selim S. 1, 2-Dipalmitoyl phosphatidylcholine, 1, 2-dipalmitoyl phosphatidic acid or 1, 2-dipalmitoyl-sn-glycerol inhibit sporangia formation and promote exponential growth of various Frankia isolates from the Casuarinaceae family. Soil Biology and Biochemistry. 1994 May 1;26(5):569-75.

[6]. Dorset DL, et al. Polymorphic forms of 1,2-dipalmitoyl-sn-glycerol: a combined X-ray and electron diffraction study. Chemistry and physics of lipids. 1988 Sep;48(1-2):19-28.

[7]. Crecelius CA, et al. A study of the molecular species of diacylglycerol, phosphatidylcholine and phosphatidylethanolamine and of cholinephosphotransferase and ethanolaminephosphotransferase activities in the type II pneumocyte. Biochimica et biophysica acta. 1984 Sep 12;795(2):247-56.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / Ethanol	1 mM	1.7577 mL	8.7886 mL	17.5772 mL	43.9429 mL
Ethanol	5 mM	0.3515 mL	1.7577 mL	3.5154 mL	8.7886 mL

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1,2-Dipalmitoyl-sn-glycerol

All PKC Isoforms

All GLUT Isoforms