(S)-Metoprolol-d7
Based on 1 Customer Validation
(S)-Metoprolol-d7 is the deuterium labeled Metoprolol. Metoprolol (Toprol) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension[1][2].
For research use only. We do not sell to patients.
- Purity : 99.08%
- CAS No.: 1292906-91-2
- Formula: C15H18D7NO3
- Molecular Weight:274.41
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1292906-91-2
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Unlabeled CAS 81024-42-2
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Appearance Solid
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Molecular Weight 274.41
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Formula C15H18D7NO3
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SMILES
[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])NC[C@H](O)COC1=CC=C(C=C1)CCOC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (364.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Benfield P, et al. Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. Drugs. 1986 May;31(5):376-429. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6442 mL | 18.2209 mL | 36.4418 mL | 91.1046 mL |
| 5 mM | 0.7288 mL | 3.6442 mL | 7.2884 mL | 18.2209 mL | |
| 10 mM | 0.3644 mL | 1.8221 mL | 3.6442 mL | 9.1105 mL | |
| 15 mM | 0.2429 mL | 1.2147 mL | 2.4295 mL | 6.0736 mL | |
| 20 mM | 0.1822 mL | 0.9110 mL | 1.8221 mL | 4.5552 mL | |
| 25 mM | 0.1458 mL | 0.7288 mL | 1.4577 mL | 3.6442 mL | |
| 30 mM | 0.1215 mL | 0.6074 mL | 1.2147 mL | 3.0368 mL | |
| 40 mM | 0.0911 mL | 0.4555 mL | 0.9110 mL | 2.2776 mL | |
| 50 mM | 0.0729 mL | 0.3644 mL | 0.7288 mL | 1.8221 mL | |
| 60 mM | 0.0607 mL | 0.3037 mL | 0.6074 mL | 1.5184 mL | |
| 80 mM | 0.0456 mL | 0.2278 mL | 0.4555 mL | 1.1388 mL | |
| 100 mM | 0.0364 mL | 0.1822 mL | 0.3644 mL | 0.9110 mL |
(S)-Metoprolol-d7 Related Classifications
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