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Cat. No.: HY-W1118851

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(S)-VAV1 degrader-1

(S)-VAV1 degrader-1 is a VAV1 molecular glue degrader with DC₅₀ = 3.07 nM. (S)-VAV1 degrader-1 is used for research on VAV1-related diseases, such as inflammation and immune-related diseases.

For research use only. We do not sell to patients.

CAS No.: 3050683-64-9
Formula: C₂₂H₁₇ClN₂O₃
Molecular Weight:392.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(S)-VAV1 degrader-1 Chemical Structure

CAS No.: 3050683-64-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

(S)-VAV1 degrader-1 (compound 211) exhibits potent VAV1 degradation activity with DC₅₀ = 3.07 nM and D_max = 97.94%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Inflammation-related Diseases

Chemical Information

CAS No. 3050683-64-9
Molecular Weight 392.84
Formula C₂₂H₁₇ClN₂O₃
SMILES

ClC1=C(C=CC=C1C2=CC=C(C=C2)N3C(=O)C=CC=C3)[C@H]4C(=O)NC(=O)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mcallister L A, et al. Targeted degradation of vav1. WO patent, WO2024151547A1. 2024.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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