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Cat. No.: HY-N21705

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Sampsonione P

Sampsonione P is an RXRα inhibitor isolated and extracted from Hypericum sampsonii. Sampsonione P inhibits RXRα transcriptional activity and can downregulate the expression of pro-inflammatory proteins such as iNOS and COX-2, thereby exerting anti-inflammatory effects. Sampsonione P has antitumor activity. Sampsonione P can be used for research on inflammatory diseases and cancer.

For research use only. We do not sell to patients.

CAS No.: 1562672-80-3
Formula: C₃₃H₄₂O₅
Molecular Weight:518.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sampsonione P Chemical Structure

CAS No.: 1562672-80-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[2]^[4]

RXR α

COX-2

iNOS

All RAR/RXR Isoforms :

All COX Isoforms :

All NO Synthase Isoforms :

All Endogenous Metabolite Isoforms :

In Vitro

Anti-cancer

The compound class including Sampsonione P (compound 6), specifically compounds 6-9, exhibits dose-dependent cytotoxicity against HeLa cells at concentrations of 5-20 μM^[2].
Sampsonione P (50 μM; 24 h) exhibits cytotoxic effects on RAW264.7 cells, reducing cell viability to 46.29%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

RAW264.7 cells
Concentration:

50 μM
Incubation Time:

24 h
Result:

Reduced cell viability to 46.29%.

Related Protocols :

Chemical Information

CAS No. 1562672-80-3
Molecular Weight 518.68
Formula C₃₃H₄₂O₅
SMILES

O=C1[C@@]23C(O[C@@H](C3)C(C)(O)C)=C(C([C@@]1(C(C)([C@@H](C2)C/C=C(C)\C)C)C/C=C(C)\C)=O)C(C4=CC=CC=C4)=O
Structure Classification
- Terpenoids
- Other Terpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shen X, et al. Programmable meroterpene synthesis. Nature communications. 2020 Jan 24;11(1):508.

[2]. Tian WJ, et al. Hypersampsones S–W, new polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii. RSC advances. 2016 May 24;6(56):50887-94.

[3]. Li Y, et al. Polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii Hance and their anti-inflammatory activity. Fitoterapia. 2023 Sep;169:105610. [Content Brief]

[4]. Li D, et al. Hyperattenins A–I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy. RSC advances. 2014 Dec 18;5(7):5277-87.

[5]. Gao W, et al. Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum. Fitoterapia. 2016 Dec;115:128-134.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Sampsonione P

All RAR/RXR Isoforms

All COX Isoforms

All NO Synthase Isoforms

All Endogenous Metabolite Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Sampsonione P Related Classifications

HY-N21705 Related Classifications

Bioz

Keywords

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