SARM1 activator 1
SARM1 activator 1 is a SARM1 activator. SARM1 activator 1 induces axon degeneration. SARM1 activator 1 can be used for research on neurodegenerative diseases.
For research use only. We do not sell to patients.
- CAS No.: 921860-34-6
- Formula: C18H19N5OS
- Molecular Weight:353.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
4 μM
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Cell viability against HeLa-SARM1-HA-3×Flag cells assessed by Cell Titer-Glo assay with IC50 ≤4 μM.
Cell viability against HeLa-SARM1-HA-3×Flag cells assessed by Cell Titer-Glo assay with IC50 ≤4 μM.
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en?oq=WO2026056874+ |
In Vitro
SARM1 activator 1 induces time-dependent changes in NAD+ and cADPR levels in HeLa-SARM1-HA-xFlag cells[1].
SARM1 activator 1 (25-50 μM; 24 h) alters axon morphology in DRG neurons of wild-type mice, and at 50 μM (48 h) alters axon morphology in DRG neurons of SARM1 knockout mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells ectopically expressing full-length SARM1 (HeLa-SARM1-HA-3×Flag and HeLa-SARM1-HA-xFlag) and HeLa cells
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Concentration:10 μM (screening); different concentrations (ATP-level measurements)
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Incubation Time:24 h (screening)
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Result:Among 1.36 million compounds, 7-(4-ethoxyphenyl)-3-((pyridin-3-ylmethyl)thio)-6,7-dihydro-5H-imidazo[2,1-c][1,2,4]triazole was identified as a superior SARM1 activator and named G10/Compound 004.
IC50 was ≤4 μM.
Cell survival ATP level (%) was shown for different G10 concentrations in HeLa-SARM1-HA-xFlag and HeLa cells.
Chemical Information
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CAS No. 921860-34-6
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Molecular Weight 353.44
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Formula C18H19N5OS
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SMILES
CCOC(C=C1)=CC=C1N2CCN3C2=NN=C3SCC4=CC=CN=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARM1 activator 1 Related Classifications
HY-186364 Related Classifications
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