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Cat. No.: HY-N19135

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SB87-H

Name: SB87-H
Brand: MedChemExpress
SKU: HY-N19135
Availability: PreOrder

(Synonyms: SNU523)

SB87-H is a Pestalone-type benzophenone compound that exists in the endophytic fungus Pestalotiopsis trachicarpicola SC-J551 and the lichen endophytic fungus Pestalotiopsis rhododendri LF-19-12. SB87-H exhibits cytotoxicity against cancer cells and epithelial cells, and possesses antibacterial activity against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and vancomycin-sensitive Enterococcus faecium. SB87-H can be used in studies related to bacteria infections.

For research use only. We do not sell to patients.

CAS No.: 163768-82-9
Formula: C₂₀H₂₀O₆
Molecular Weight:356.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SB87-H Chemical Structure

CAS No.: 163768-82-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Anti-cancerBacterial Infection

Anti-cancer

SB87-H (0.016-50 μM) potently induces cytotoxicity in A549, HeLa, HepG2, MCF-7, and Vero cells with IC₅₀ values ranging from 1.5-2.2 μM^[1].

Bacterial Infection

SB87-H (compound 9) (0.31-10 μg/mL; 6-8 h) inhibits the growth of Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and vancomycin-susceptible Enterococcus faecium with an MIC of 10 μg/mL, and shows no activity against vancomycin-resistant Enterococcus faecium^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 163768-82-9
Molecular Weight 356.37
Formula C₂₀H₂₀O₆
SMILES

O=CC1=C(C=C(C(C/C=C(C)\C)=C1C(C2=C(C=C(C)C=C2O)O)=O)O)O
Synonyms

SNU523
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Pestalotiopsis trachicarpicola SC-J551
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jiang Z, et al. Pestalotinones A-D, new benzophenone antibiotics from endophytic fungus Pestalotiopsis trachicarpicola SC-J551. The Journal of antibiotics. 2022 Apr;75(4):207-212. [Content Brief]

[2]. Song F. Antimicrobial Natural Products. Antibiotics. 2022 Dec 7;11(12):1765.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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