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Cat. No.: HY-N19921

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Schizotenuin A

Schizotenuin A is a Aβ and hIAPP fibrillation inhibitor with human-derived IC₅₀ values of 2.93 µM and 0.58 µM, respectively, and exhibits antioxidant activity. Schizotenuin A scavenges DPPH free radicals and inhibits lipid peroxidation in rat liver microsomes. Schizotenuin A can be used in research related to Alzheimer's disease and type 2 diabetes.

For research use only. We do not sell to patients.

CAS No.: 144608-09-3
Formula: C₃₆H₂₈O₁₆
Molecular Weight:716.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Schizotenuin A Chemical Structure

CAS No.: 144608-09-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Aβ/Tau/α-Synuclein AggregationFerroptosis

Aβ/Tau/α-Synuclein Aggregation

Schizotenuin A (1-100 μM; 24 h) potently inhibits Aβ42 fibrillization with an IC₅₀ of 2.93 μM in a dose-dependent manner^[1].
Schizotenuin A (100 μM; 24 h) significantly reduces and shortens Aβ42 fibrils as visualized by TEM^[1].

Ferroptosis

Schizotenuin A (compound 40) inhibits lipid peroxidation in rat liver microsomes with an IC₅₀ of 36.25 μM, which is more potent than (+)-α-Tocopherol (HY-N0683)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 144608-09-3
Molecular Weight 716.60
Formula C₃₆H₂₈O₁₆
SMILES

OC(C=C1C[C@H](C(O)=O)OC(C(C2=CC(/C=C/C(O[C@@H](C(O)=O)CC3=CC(O)=C(C=C3)O)=O)=C4)=C(C5=CC(O)=C(C=C5)O)OC2=C4O)=O)=C(C=C1)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sun J, et al. Inhibitory activities of phenylpropanoids from Lycopus lucidus on amyloid aggregation related to Alzheimer's disease and type 2 diabetes. Journal of natural medicines. 2020 Jun;74(3):579-583. [Content Brief]

[2]. Chand K, et al. A review on antioxidant potential of bioactive heterocycle benzofuran: Natural and synthetic derivatives. Pharmacological reports : PR. 2017 Apr;69(2):281-295. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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