SDH-IN-47
SDH-IN-47 is a succinate dehydrogenase (SDH) inhibitor, with an IC50 value of 1.80 μM against SDH from Botrytis cinerea. SDH-IN-47 binds to the active site of SDH, interferes with fungal growth, disrupts mycelial morphology and cell membrane integrity, and induces depolarization of mitochondrial membrane potential. SDH-IN-47 exhibits in vitro and in vivo antifungal activities against a variety of plant pathogenic fungi, including Botrytis cinerea, Phytophthora capsici, and Valsa mali, and can be used for studies on related fungal infections.
For research use only. We do not sell to patients.
- Formula: C17H10F4N2O3S
- Molecular Weight:398.33
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
SDH 1.80 μM (IC50, Botrytis cinerea) |
In Vitro
SDH-IN-47 (1.0 mg/L) disrupts the surface morphology and intracellular ultrastructure of Botrytis cinerea hyphae, inducing plasmolysis and cytoplasmic disorder[1].
SDH-IN-47 (0.3 mg/L) disrupts the membrane integrity of Botrytis cinerea hyphae, allowing PI to penetrate into the cells, and also dissipates the mitochondrial membrane potential of Botrytis cinerea hyphae[1].
SDH-IN-47 (0.6-10 mg/L; 5 min) potently inhibits succinate dehydrogenase in Botrytis cinerea, with an IC50 value of 1.80 μM[1].
SDH-IN-47 binds tightly to the SDH active site of Botrytis cinerea, with a CDOCKER interaction energy of -44.03 kcal/mol, and forms multiple hydrogen bonds and hydrophobic interactions with key residues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 398.33
-
Formula C17H10F4N2O3S
-
SMILES
O=C(NC1=NC(C(F)(F)F)=CS1)C2=CC=C(OC3=CC=C(F)C=C3O)C=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SDH-IN-47 Related Classifications
HY-187993 Related Classifications
Powered by Bioz