SDH-IN-53
SDH-IN-53 is an Antifungal agent and SDH inhibitor, with SDH IC50 values of 3.13, 1.19, and 2.83 μg/mL against G. zeae, A. solani, and C. fructicola, respectively. SDH-IN-53 induces excessive ROS production and mitochondrial membrane potential depolarization. SDH-IN-53 inhibits mycelial growth of plant pathogenic fungi and oomycetes. SDH-IN-53 has no significant effect on seed germination of wheat, tomato, and cabbage. SDH-IN-53 can be used for research on tomato early blight.
For research use only. We do not sell to patients.
- CAS No.: 3082183-65-8
- Formula: C15H14F2N2O4
- Molecular Weight:324.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
SDH-IN-53 (25.0 μg/mL for initial screening; 0.195-3.13 μg/mL for mycelial growth assay) inhibits the mycelial growth of G. zeae, A. solani, and C. fructicola, with EC50 values of 0.679, 0.424, and 0.384 μg/mL, respectively[1].
SDH-IN-53 (12.5 μg/mL) exhibits broad-spectrum inhibitory activity (>75.0%) against eight plant pathogenic fungi and two oomycetes, with EC50 values ranging from 0.258 to 3.63 μg/mL[1].
SDH-IN-53 (100-200 μg/mL) protects tomato fruit against A. solani early blight, with a protective activity of 83.8% at 200 μg/mL and 71.2% at 100 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3082183-65-8
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Molecular Weight 324.28
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Formula C15H14F2N2O4
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SMILES
O=C(NNC1=CC=C(F)C=C1F)C2=CC(OC)=C(O)C(OC)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SDH-IN-53 Related Classifications
HY-189783 Related Classifications
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Keywords
- SDH-IN-53
- 3082183-65-8
- Fungal
- Reactive Oxygen Species (ROS)
- Mitochondrial Metabolism
- anti-oomycete
- broad-spectrum antifungal
- mitochondrial complex II inhibitor
- mitochondrial membrane potential depolarization
- reactive oxygen species overproduction
- succinate dehydrogenase inhibitor
- succinate oxidation
- tomato early blight
- tricarboxylic acid cycle
- ubiquinone
- Inhibitor
- inhibitor
- inhibit