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93 Results for "

β subtype

" in MedChemExpress (MCE) Product Catalog:

Products (93)

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Levamisole

17 Cited Publications

Cat. No.: HY-A0106

CAS No.: 14769-73-4

Synonyms: (-)-Tetramisole

Target:

nAChR Parasite

Research Areas:

Infection Inflammation/Immunology Cancer

Levamisole ((-)-Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC₅₀=300 μM) and α3β4 (EC₅₀=100 μM) subtype of nAChRs. Orally active .

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Fresolimumab

2 Cited Publications

Cat. No.: HY-P99020

CAS No.: 948564-73-6

Synonyms: GC1008

Fresolimumab (GC1008) is a human monoclonal antibody against TGF-β that neutralizes all mammalian active subtypes of TGF-β. The binding affinity of Fresolimumab to TGF-β2 is 1.8 nM. Fresolimumab improves Bleomycin (HY-108345)-induced acute lung injury. Fresolimumab radiolabeled with ⁸⁹Zr can be used for PET analysis of TGF-β expression, antibody uptake and organ distribution. Fresolimumab can be used in the study of cancer, osteogenesis imperfecta, fibrosis and kidney disease .

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2,4-Di-tert-butylphenol

2 Cited Publications

Cat. No.: HY-W014589

CAS No.: 96-76-4

Synonyms: 2,4-DTBP

Category:

Monophenols Metabolic Disease Phenols Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Fungal Apoptosis RAR/RXR Amyloid-β

2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances .

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Rivanicline hemioxalate

2 Cited Publications

Cat. No.: HY-13225B

Purity: ≥95.0%

Synonyms: RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate

Target:

nAChR

Research Areas:

Neurological Disease

Rivanicline (RJR-2403) hemioxalate is a neuronal nicotinic receptor agonist. Rivanicline hemioxalate is highly selective for the rat brain cortex nAChRs (K_i = 26 nM, EC₅₀ of 732 nM) and α4β2 subtype (K_i = 26 nM, EC₅₀ = 16 μM). Rivanicline hemioxalate can significantly restore the learning impairment and cognitive dysfunction. Rivanicline hemioxalate can be used for the study of neurodegenerative diseases (such as schizophrenia or Alzheimer's disease) .

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