37

Lificiguat

37 Publications Verification

Cat. No.: HY-14927

CAS No.: 170632-47-0

Purity: 99.70%

Synonyms: YC-1

Target:

Guanylate Cyclase

Research Areas:

Cardiovascular Disease Cancer

Lificiguat binds to the β subunit of soluble guanylyl cyclase(sGC) with K_d of 0.6-1.1 μM in the presence of CO.

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34

Kartogenin

34 Cited Publications

Cat. No.: HY-16268

CAS No.: 4727-31-5

Synonyms: KGN

Target:

TGF-beta/Smad

Research Areas:

Inflammation/Immunology

Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC₅₀: 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .

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34

Kartogenin sodium

34 Cited Publications

Cat. No.: HY-16268A

CAS No.: 1401168-39-5

Synonyms: KGN sodium

Target:

TGF-beta/Smad

Research Areas:

Inflammation/Immunology

Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC₅₀: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .

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8

Rifaximin

8 Cited Publications

Cat. No.: HY-13234

CAS No.: 80621-81-4

Purity: 99.64%

Target:

Bacterial Antibiotic DNA/RNA Synthesis

Research Areas:

Infection Cancer

Rifaximin, a gastrointestinal-selective antibiotic, binds the β-subunit of bacterial DNA-dependent RNA polymerase, resulting in inhibition of bacterial RNA synthesis. Rifaximin susceptibility is higher against Gram-positive strains (MIC: 0.03-5 mg/ml) compared to Gram-negative bacteria (MIC: 8-50 mg/mL) .

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7

Acriflavine

7 Cited Publications

Cat. No.: HY-100575

CAS No.: 8048-52-0

Purity: ≥98.0%

Synonyms: Acriflavinium chloride 3,6-Acridinediamine mix

Target:

Fluorescent Dye Monocarboxylate Transporter Bacterial Fungal HIF/HIF Prolyl-Hydroxylase SARS-CoV

Research Areas:

Infection Cancer

Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 .

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7

Acriflavine hydrochloride

7 Cited Publications

Cat. No.: HY-W088075

CAS No.: 69235-50-3

Synonyms: Acriflavinium chloride hydrochloride

Target:

Fluorescent Dye HIF/HIF Prolyl-Hydroxylase Bacterial SARS-CoV Monocarboxylate Transporter Fungal

Research Areas:

Infection Cancer

Acriflavine (Acriflavinium chloride) hydrochloride is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine hydrochloride is an antiseptic agent. Acriflavine hydrochloride is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine hydrochloride inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine hydrochloride is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine hydrochloride is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 .

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5

COH29

5 Cited Publications

Cat. No.: HY-19931

CAS No.: 1190932-38-7

Synonyms: RNR Inhibitor COH29

Target:

DNA/RNA Synthesis

Research Areas:

Cancer

COH29 (RNR Inhibitor COH29) is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity. COH29 inhibits α and β subunit of RNR with IC₅₀s of 16 μM.

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5

JNJ-28583113

5 Cited Publications

Cat. No.: HY-149143

CAS No.: 2765255-93-2

Purity: 98.82%

Target:

TRP Channel

Research Areas:

Inflammation/Immunology

JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3α and β subunits. JNJ-28583113 protects cells from oxidative stress induced cell death. JNJ-28583113 also suppresses cytokine release in response to pro-inflammatory stimuli in microglia .

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5

Beta-NGF Protein, Human (CHO)

5 Cited Publications

Cat. No.: HY-P73316

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: NGF; Beta-NGF; Prev. NGFB; Pro-Nerve Growth Factor Long; Beta-Nerve Growth Factor; HSAN5; Nerve Growth Factor (Beta Polypeptide); Nerve Growth Factor; Nerve Growth Factor, Beta subunit

Species:

Human

Source:

CHO

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