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62 Results for "

ADR

" in MedChemExpress (MCE) Product Catalog:

Products (62)

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Doxorubicin hydrochloride

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Cat. No.: HY-15142

CAS No.: 25316-40-9

Purity: 99.90%

Synonyms: Hydroxydaunorubicin hydrochloride; ADR

Category:

Infection Quinones Microorganisms Anthraquinones Disease Research Fields

Target:

Topoisomerase ADC Payloads AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye

Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

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Dexrazoxane

20 Cited Publications

Cat. No.: HY-B0581

CAS No.: 24584-09-6

Synonyms: ICRF-187; ADR-529; NSC-169780

Target:

Ferroptosis Apoptosis

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer

Dexrazoxane, as an intracellular iron chelating agent, reduces the formation of superoxide radicals and has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities. Dexrazoxane inhibits ferroptosis of H9c2 cells by inhibiting HMGB1. Dexrazoxane induces DNA damage and apoptosis in human fibrosarcoma cells .

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Dexrazoxane hydrochloride

20 Cited Publications

Cat. No.: HY-76201

CAS No.: 149003-01-0

Synonyms: ICRF-187 hydrochloride; ADR-529 hydrochloride; NSC-169780 hydrochloride

Target:

Apoptosis Ferroptosis

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer

Dexrazoxane hydrochloride (ICRF-187 hydrochloride) is a heart protectant that can help preserve ovarian function and fertility. Dexrazoxane hydrochloride has antioxidant and anti-inflammatory properties, can cross the blood-brain barrier, improves motor function disorders, and offers neuroprotective effects, making it useful in the study of neurodegenerative diseases .

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Doxorubicin hydrochloride (Standard)

6 Cited Publications

Cat. No.: HY-15142R

CAS No.: 25316-40-9

Synonyms: Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)

Category:

Quinones Microorganisms Anthraquinones

Target:

Reference Standards Topoisomerase ADC Payloads AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye

Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

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