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N-Nitrosodiethylamine

9 Cited Publications

Cat. No.: HY-N7434

CAS No.: 55-18-5

Synonyms: Diethylnitrosamine; DEN; DENA

Category:

Natural Products Plants Other Families Extract Disease Research Fields Cancer

Target:

DNA/RNA Synthesis

N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

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N-Nitrosodiethylamine-d10

Cat. No.: HY-N7434S1

CAS No.: 1219794-54-3

Synonyms: Diethylnitrosamine-d₁₀; DEN-d₁₀; DENA-d₁₀

N-Nitrosodiethylamine-d₁₀ is the deuterium labeled N-Nitrosodiethylamine . N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

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Nodularin

Cat. No.: HY-P2040

CAS No.: 118399-22-7

Category:

Cyclopeptides Ketones, Aldehydes, Acids Marine natural products Plants Other Families Extract

Target:

Phosphatase Apoptosis Caspase Bcl-2 Family p38 MAPK Ribosomal S6 Kinase (RSK) Reactive Oxygen Species (ROS)

Nodularin is a hepatotoxin, tumor promoter, and protein phosphatase inhibitor. Nodularin induces apoptosis (apoptosis) in normal cells (including caspase activation, upregulation of Bcl-XS, and upregulation of BAX/P53), triggers hyperphosphorylation of the MAPK/ERK, mTOR/S6K and p38 MAPK signaling pathways, and induces oxidative stress, endoplasmic reticulum membrane instability, peroxisome proliferation and increased lysosomal enzyme activity. Nodularin promotes DEN (HY-N7434)-initiated hepatocyte proliferation and adenoma formation, and inhibits proliferation, phagocytosis and chemotaxis of normal lymphocytes, oocyte maturation and vitellogenesis, as well as angiogenesis. Nodularin exhibits hepatotoxicity, reproductive and endocrine toxicity, and embryonic developmental toxicity in various animal models. Nodularin can be used in studies related to liver cancer, hepatotoxicity and reproductive endocrine toxicity .

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Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate

Cat. No.: HY-P5313A

Target:

Dengue Virus

Research Areas:

Infection

Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate is a DEN protease substrate, which can be used in research related to dengue virus (drug development) .

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N-Nitrosodiethylamine-d4

Cat. No.: HY-N7434S

CAS No.: 1346603-41-5

Synonyms: Diethylnitrosamine-d₄; DEN-d₄; DENA-d₄

N-Nitrosodiethylamine-d₄ is the deuterium labeled N-Nitrosodiethylamine . N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

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N-Nitrosodiethylamine (Standard)

Cat. No.: HY-N7434R

CAS No.: 55-18-5

Synonyms: Diethylnitrosamine (Standard); DEN (Standard); DENA (Standard)

Category:

Natural Products Plants Other Families Extract

Target:

Reference Standards DNA/RNA Synthesis

N-Nitrosodiethylamine (Standard) is the analytical standard of N-Nitrosodiethylamine. This product is intended for research and analytical applications. N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

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