20

GB1107

20 Publications Verification

Cat. No.: HY-114409

CAS No.: 1978336-61-6

Purity: 99.92%

Target:

Galectin

Research Areas:

Cancer

GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a K_d of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model .

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6

GAL-021

6 Cited Publications

Cat. No.: HY-101422

CAS No.: 1380341-99-0

Purity: 99.93%

Target:

Potassium Channel

Research Areas:

Inflammation/Immunology

GAL-021 is a potent BK_Ca-channel blocker. GAL-021 inhibits K_Ca1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates .

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6

X-GAL

6 Cited Publications

Cat. No.: HY-15934

CAS No.: 7240-90-6

Synonyms: BCIG

X-GAL (BCIG) is a widely used chromogenic β-galactosidase substrate. X-GAL is a colorless compound until cleaved by β-galactosidase, at which point X-GAL turns to an insoluble and detectable blue compound, making X-GAL particularly useful in techniques such as blue-white screening for cloning in bacteria. X-GAL can also be used for detection of β-galactosidase activity .

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5

Thiodigalactoside

5 Cited Publications

Cat. No.: HY-130208

CAS No.: 51555-87-4

Purity: 99.97%

Synonyms: TDG

Target:

Galectin

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with K_d values of 24 μM, 49 μM for GAL1 and GAL3, respectively . Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats .

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5

HT-2157

5 Cited Publications

Cat. No.: HY-100717

CAS No.: 303149-14-6

Purity: ≥98.0%

Synonyms: SNAP 37889

Target:

Neuropeptide Y Receptor

Research Areas:

Neurological Disease Endocrinology

HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal₃).

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4

Galectin-9/LGALS9 Protein, Human (HEK293, His)

4 Cited Publications

Cat. No.: HY-P70535

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: LGALS9; Ecalectin; GALectin 9; GAL-9; LGALS9A; Urate Transporter/Channel Protein; Lectin, GALactoside-Binding, Soluble, 9; GALectin; Tumor Antigen HOM-HD-21; HUAT; GALectin-9

Species:

Human

Source:

HEK293

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3

Galectin-9/LGALS9 Protein, Mouse (GST)

3 Cited Publications

Cat. No.: HY-P72637

Purity: ≥ 85%, as determined by reducing SDS-PAGE.

Synonyms: LGALS9; Ecalectin; GALectin 9; GAL-9; LGALS9A; Urate Transporter/Channel Protein; Lectin, GALactoside-Binding, Soluble, 9; GALectin; Tumor Antigen HOM-HD-21; HUAT; GALectin-9

Species:

Mouse

Source:

E. coli

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3

BMS-687453

3 Cited Publications

Cat. No.: HY-10678

CAS No.: 1000998-59-3

Purity: 99.31%

Target:

PPAR

Research Areas:

Cardiovascular Disease

BMS-687453 is a potent and selective PPARα agonist, with an EC₅₀ and IC₅₀ of 10 nM and 260 nM for human PPARα and 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays.

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2

Galectin-3/LGALS3 Protein, Mouse (HEK293, His)

2 Cited Publications

Cat. No.: HY-P77684

Purity: ≥ 95%, as determined by Bis-Tris PAGE.

Synonyms: LGALS3; MAC-2; Prev. LGALS2; MAC2; GALIG; GALactoside-Binding Protein; Epididymis Secretory Sperm Binding Protein; MAC-2 Antigen; Advanced Glycation End-Product Receptor 3; Mac-2 Antigen; Lectin, GALactoside-Binding, Soluble, 3; GALectin; Carbohydrate-Binding Protein 35; CBP 35; GALactose-Specific Lectin 3; CBP35; Laminin-Binding Protein; GAL-3; IgE-Binding Protein; GAL3; 35 KDa Lectin; L-31; Lectin L-29; L31; GALectin-3; GALectin 3; GALBP

Species:

Mouse

Source:

HEK293

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2

Spexin

2 Cited Publications

Cat. No.: HY-P1723

CAS No.: 1370290-58-6

Synonyms: Neuropeptide Q

Target:

Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy

Research Areas:

Cardiovascular Disease Neurological Disease

Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .

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2

Migalastat hydrochloride

2 Cited Publications

Cat. No.: HY-14929A

CAS No.: 75172-81-5

Purity: 99.70%

Synonyms: GR181413A

Target:

Glycosidase

Research Areas:

Others

Migalastat (GR181413A free base) hydrochloride is an orally active α-galactosidase A molecular chaperone, with an IC₅₀ value of 0.04 μM for human α-Gal A. Migalastat binds to the active site of certain unstable mutant forms of α-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant α-galactosidase A to exhibit biological activity .

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1

Galectin-3/LGALS3 Protein, Mouse

1 Cited Publications

Cat. No.: HY-P79079

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: LGALS3; MAC-2; Prev. LGALS2; MAC2; GALIG; GALactoside-Binding Protein; Epididymis Secretory Sperm Binding Protein; MAC-2 Antigen; Advanced Glycation End-Product Receptor 3; Mac-2 Antigen; Lectin, GALactoside-Binding, Soluble, 3; GALectin; Carbohydrate-Binding Protein 35; CBP 35; GALactose-Specific Lectin 3; CBP35; Laminin-Binding Protein; GAL-3; IgE-Binding Protein; GAL3; 35 KDa Lectin; L-31; Lectin L-29; L31; GALectin-3; GALectin 3; GALBP

Species:

Mouse

Source:

E. coli

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1

Galectin-1/LGALS1 Protein, Mouse

1 Cited Publications

Cat. No.: HY-P74131

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: LGALS1; GALaptin; GALectin 1; HLBP14; Lectin, GALactoside-Binding, Soluble, 1; GAL-1; GBP; HBL; Beta-GALactoside-Binding Lectin L-14-I; HPL; Putative MAPK-Activating Protein PM12; Epididymis Secretory Sperm Binding Protein; 14 KDa Laminin-Binding Protein

Species:

Mouse

Source:

E. coli

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1

O-Glycosidase

1 Cited Publications

Cat. No.: HY-KE7057

O-Glycosidase is highly specific and can release Galβ1-3GalNAc from serine, threonine residues or as part of a glycopeptide or glycoprotein. Applied to glycoprotein biosynthesis analysis, O-glycan bioactive protein O-glycosylation detection and binding site analysis.

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1

Animal-Free Galectin-12 Protein, Human (His)

1 Cited Publications

Cat. No.: HY-P700074AF

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: LGALS12; GALectin-12; GALectin 12; Testicular Secretory Protein Li 26; GRIP1; GALectin; GALectin-Related Inhibitor Of Proliferation; GAL-12; Lectin, GALactoside-Binding, Soluble, 12; GAL12

Species:

Human

Source:

E. coli

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1

SBB-Analogue (GL13) Biotin

1 Cited Publications

Cat. No.: HY-158742

CAS No.: 2171036-89-6

Purity: 99.30%

Synonyms: GL13; SBB-A-B

Target:

Tyrosinase

Research Areas:

Others

SBB-Analogue (GL13) Biotin (GL13; SBB-A-B) consists of a Sudan Black B (SBB) (HY-D0213) derivative conjugated with biotin. SBB-Analogue (GL13) Biotin potently detects senescent cells and eliminates the drawback of false-positive staining caused by serum starvation and cell fusion in SA-β-gal assays. SBB-Analogue (GL13) Biotin can be used in flow cytometry, immunofluorescence analysis, and other applications .

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