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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
171 Results for "
HL60
" in MedChemExpress (MCE) Product Catalog:
Products (171)
171 Results for "HL60" in MCE Product Catalog:
8
Target:
Research Areas:
Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects .
8
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Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .
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8 Publications Verification
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6 Cited Publications
Synonyms: S-p-Bromobenzylglutathione cyclopentyl diester
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BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity .
3
Category:
Leguminosae/Fabaceae Extract Sophora flavescens Aiton Extract Plant Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Cancer
Target:
3
3 Cited Publications
Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research .
3
Category:
Triterpenes Plant Terpenoids Burseraceae Extract Other Families Extract Disease Research Fields Cancer Boswellia serrata Extract
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2
Category:
Natural Products Plant Other Families Extract Endogenous metabolite Disease Research Fields Cancer
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2
2 Cited Publications
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2
2 Cited Publications
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PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.
2
2 Cited Publications
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TEI-9647, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9647 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9647 inhibits bone resorption and HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9647 has the potential for suppressing the excessive bone resorption and osteoclast formation in Paget's disease .
2
Category:
Plant Metabolic Disease Phenols Polyphenols Other Families Extract Disease Research Fields
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1
1 Cited Publications
Cat. No.: HY-33350
CAS No.: 92953-10-1
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Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent .
1
1 Cited Publications
Cat. No.: HY-N2113
CAS No.: 80508-81-2
Category:
Plant Terpenoids Sesquiterpenes Isodon japonicus (Burm. f.) H. Hara/Rabdosia japonica (Burm. f.) Hara Extract Disease Research Fields Cancer Labiatae Extract
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1
1 Cited Publications
Synonyms: GPR183 antagonist-1
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SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice .
1
1 Cited Publications
Cat. No.: HY-N12153
CAS No.: 220114-30-7
Category:
Triterpenes Plant Terpenoids Camellia sinensis (L.) O. Ktze. Extract Pentacyclic Triterpenoids Theaceae Extract
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1
1 Cited Publications
Cat. No.: HY-19969
CAS No.: 163769-88-8
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Research Areas:
YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [ 125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0 and 0.57 μM .
1
1 Cited Publications
SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor. SKI-178 is cytotoxic at IC50 concentrations ranging from 1.8 to 0.1 μM in both agent sensitive and multi-agent resistant cancer cell lines (i.e., MTR3, NCI-ADR and HL60/VCR cells). SKI-178 induces apoptosis in a CDK1-dependent manner in human acute myeloid leukemia cell lines .
1
1 Cited Publications
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TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research .
1
1 Cited Publications
Cat. No.: HY-P70990
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PADI4; Protein-Arginine Deiminase Type IV; Prev. PADI5; HL-60 PAD; PDI5; PAD4; PDI4; Peptidyl Arginine Deiminase Type IV; PAD; Peptidylarginine Deiminase IV; Peptidyl Arginine Deiminase, Type IV; PADI-H Protein; Peptidyl Arginine Deiminase, Type V; PADI4
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
