7933 Results for "

inflammatory

" in MedChemExpress (MCE) Product Catalog:

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1385

Chloroquine phosphate

1385 Publications Verification

Cat. No.: HY-17589

CAS No.: 50-63-5

Target:

Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic

Research Areas:

Infection Inflammation/Immunology Cancer

Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

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1385

Chloroquine

1385 Publications Verification

Cat. No.: HY-17589A

CAS No.: 54-05-7

Target:

Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic

Research Areas:

Infection Inflammation/Immunology Cancer

Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

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1385

Chloroquine dihydrochloride

1385 Publications Verification

Cat. No.: HY-17589B

CAS No.: 3545-67-3

Target:

Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic

Research Areas:

Infection Inflammation/Immunology Cancer

Chloroquine dihydrochloride is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine dihydrochloride is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine dihydrochloride is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM) .

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843

Dorsomorphin dihydrochloride

843 Cited Publications

Cat. No.: HY-13418

CAS No.: 1219168-18-9

Purity: 99.7%

Synonyms: BML-275 dihydrochloride; Compound C dihydrochloride

Target:

Organoid AMPK TGF-β Receptor Autophagy

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a K_i of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).

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843

Dorsomorphin

843 Cited Publications

Cat. No.: HY-13418A

CAS No.: 866405-64-3

Purity: 99.10%

Synonyms: BML-275; Compound C

Target:

Organoid AMPK TGF-β Receptor Autophagy

Research Areas:

Inflammation/Immunology Cancer

Dorsomorphin (BML-275; Compound C) is a selective and ATP-competitive AMPK inhibitor (K_i=109 nM in the absence of AMP). Dorsomorphin selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599) .

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629

Y-27632

629 Cited Publications

Cat. No.: HY-10071

CAS No.: 146986-50-7

Purity: 99.46%

Target:

ROCK NADPH Oxidase mTOR Reactive Oxygen Species (ROS) NF-κB Apoptosis Akt Autophagy PAK Ras

Research Areas:

Cancer

Y-27632 is a ROCK inhibitor with K_i values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade .

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629

Y-27632 hydrochloride hydrate

629 Cited Publications

Cat. No.: HY-10071A

CAS No.: 331752-47-7

Target:

ROCK NF-κB Apoptosis Autophagy Akt mTOR NADPH Oxidase Reactive Oxygen Species (ROS) PAK Ras

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Y-27632 hydrochloride hydrate is a ROCK inhibitor with K_i values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 hydrochloride hydrate exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 hydrochloride hydrate enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 hydrochloride hydrate induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 hydrochloride hydrate promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade .

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550

Resatorvid

550 Cited Publications

Cat. No.: HY-11109

CAS No.: 243984-11-4

Purity: 98.92%

Synonyms: TAK-242; CLI-095

Target:

Toll-like Receptor (TLR) TNF Receptor Interleukin Related Autophagy

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC_50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases .

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415

Dexamethasone

415 Cited Publications

Cat. No.: HY-14648

CAS No.: 50-02-2

Purity: 99.86%

Synonyms: Hexadecadrol; Prednisolone F

Target:

Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic ADC Payloads

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research .

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415

Dexamethasone (Water Soluble)

415 Cited Publications

Cat. No.: HY-14648C

CAS No.: 50-02-2

Purity: ≥98.0%

Synonyms: Dexamethasone cyclodextrin complex

Target:

Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic

Research Areas:

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone (HY-14648). Dexamethasone is a glucocorticoid receptor agonist, apoptosis inducer, and a common disease inducer in experimental animals. It can be used to construct models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has the potential to be used in COVID-19 research .(Sale size is the weight of dexamethasone)

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179

Resveratrol

179 Cited Publications

Cat. No.: HY-16561

CAS No.: 501-36-0

Synonyms: trans-Resveratrol; SRT501

Category:

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