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626 Results for "

platelet aggregation

" in MedChemExpress (MCE) Product Catalog:

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Clopidogrel hydrogen sulfate

33 Publications Verification

Cat. No.: HY-17459

CAS No.: 120202-66-6

Synonyms: (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate

Target:

Cytochrome P450 P2Y Receptor

Research Areas:

Cardiovascular Disease Cancer

Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC₅₀s of 18.2 nM and 524 nM, respectively . Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation ．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor .

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Prostaglandin E1

22 Cited Publications

Cat. No.: HY-B0131

CAS No.: 745-65-3

Synonyms: Alprostadil; PGE1

Category:

Cardiovascular Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields

Target:

Prostaglandin Receptor Endogenous Metabolite

Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

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Tolvaptan

20 Cited Publications

Cat. No.: HY-17000

CAS No.: 150683-30-0

Synonyms: OPC-41061

Target:

Vasopressin Receptor Autophagy

Research Areas:

Cardiovascular Disease Endocrinology Cancer

Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V₂R) antagonist with an IC₅₀ of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation. Tolvaptan induces cell apoposis and affects cell cycle. Tolvaptan can be used for the research of hyponatremia .

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YM-254890

20 Cited Publications

Cat. No.: HY-111557

CAS No.: 568580-02-9

Purity: ≥95.0%

Category:

Cardiovascular Disease Natural Products Microorganisms Disease Research Fields

Target:

P2Y Receptor

YM-254890 is a selective G_αq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y₁ signal transduction pathway, with an IC₅₀ value below 0.6 μM .

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Adenosine

19 Cited Publications

Cat. No.: HY-B0228

CAS No.: 58-61-7

Synonyms: Adenine riboside; D-Adenosine

Category:

Natural Products Microorganisms Marine natural products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Environmental Pollutants Autophagy Nucleoside Antimetabolite/Analog Endogenous Metabolite Apoptosis

Adenosine (Adenine riboside), a ubiquitous and BBB-permeable endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

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