959 Results for "

pulmonary

" in MedChemExpress (MCE) Product Catalog:

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105

Tofacitinib

105 Publications Verification

Cat. No.: HY-40354

CAS No.: 477600-75-2

Synonyms: Tasocitinib; CP-690550

Target:

JAK STAT NF-κB

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology

Tofacitinib (Tasocitinib) is an orally active, blood-brain barrier permeable selective inhibitor of JAK1/JAK3. Tofacitinib blocks the JAK-STAT/NF-κB signaling pathway, inhibits cytokine signal transduction, phosphorylation of STAT1/STAT5, and suppresses innate and adaptive immune responses. Tofacitinib can be used in research related to major depressive disorder, rheumatoid arthritis, pulmonary diseases, systemic lupus erythematosus, and immune-mediated liver injury .

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105

Tofacitinib citrate

105 Publications Verification

Cat. No.: HY-40354A

CAS No.: 540737-29-9

Synonyms: Tasocitinib citrate; CP-690550 citrate

Target:

JAK STAT NF-κB

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology

Tofacitinib citrate (Tasocitinib citrate) is an orally active, blood-brain barrier permeable selective inhibitor of JAK1/JAK3. Tofacitinib citrate blocks the JAK-STAT/NF-κB signaling pathway, inhibits cytokine signal transduction, phosphorylation of STAT1/STAT5, and suppresses innate and adaptive immune responses. Tofacitinib citrate can be used in research related to major depressive disorder, rheumatoid arthritis, pulmonary diseases, systemic lupus erythematosus, and immune-mediated liver injury .

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Methotrexate

94 Cited Publications

Cat. No.: HY-14519

CAS No.: 59-05-2

Purity: 99.87%

Synonyms: Amethopterin; CL14377; WR19039

Target:

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Research Areas:

Inflammation/Immunology Cancer

Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .

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Methotrexate hydrate

94 Cited Publications

Cat. No.: HY-14519B

CAS No.: 133073-73-1

Purity: 98.41%

Synonyms: Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate

Target:

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Methotrexate hydrate (Amethopterin hydrate; CL14377 hydrate; WR19039 hydrate) is an orally active antifolate (Antifolate). Methotrexate hydrate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate hydrate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate hydrate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate hydrate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .

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Methotrexate disodium

94 Cited Publications

Cat. No.: HY-14519A

CAS No.: 7413-34-5

Purity: 99.71%

Synonyms: Amethopterin disodium; CL14377 disodium; WR19039 disodium

Target:

Antifolate Dihydrofolate reductase (DHFR) NO Synthase COX Interleukin Related

Methotrexate disodium (Amethopterin disodium; CL14377 disodium; WR19039 disodium) is an orally active antifolate (Antifolate). Methotrexate disodium inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate disodium promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate disodium induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate disodium is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer .

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Sapanisertib

59 Cited Publications

Cat. No.: HY-13328

CAS No.: 1224844-38-5

Purity: 99.63%

Synonyms: INK-128; MLN0128; TAK-228

Target:

mTOR Apoptosis Akt ERK CDK Ribosomal S6 Kinase (RSK) Collagen HIF/HIF Prolyl-Hydroxylase Wnt

Research Areas:

Cardiovascular Disease Inflammation/Immunology Cancer

Sapanisertib (INK-128; MLN0128; TAK-228) is an orally active dual mTORC1/mTORC2 inhibitor. Sapanisertib directly and simultaneously inhibits mTORC1/2 activity through competitive binding with ATP, thereby comprehensively blocking downstream processes such as protein and lipid synthesis and cytoskeletal reorganization, consequently suppressing tumor cell proliferation and promoting apoptosis. Sapanisertib is applicable to research on melanoma, ovarian cancer, pulmonary fibrosis, and hematological malignancies .

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Zenidolol

52 Cited Publications

Cat. No.: HY-100543

CAS No.: 72795-26-7

Purity: 99.60%

Synonyms: ICI-118551

Target:

Adrenergic Receptor Apoptosis Caspase Bcl-2 Family HIF/HIF Prolyl-Hydroxylase

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Zenidolol (ICI-118551) is a selective β2-adrenergic receptor antagonist with K_i values of Zenidolol for β2, β1 and β3 adrenergic receptors of 0.7, 49.5 and 611 nM, respectively. Zenidolol exerts antitumor effects via inducing apoptosis, inhibiting tumor sphere formation, and downregulating the HIF pathway by blocking β2-AR on tumor cells. Zenidolol exhibits a unique pulmonary vessel-specific vasodilatory effect in mouse models. Zenidolol can be used as an intraocular pressure-lowering agent in ophthalmic disease research .

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