68

68 Publications Verification

Target:

RIG-I-like receptor (RLR) Toll-like Receptor (TLR) Apoptosis

Research Areas:

Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia .

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59

Bedaquiline

59 Cited Publications

Cat. No.: HY-14881

CAS No.: 843663-66-1

Purity: 99.98%

Synonyms: TMC207; R207910

Target:

Bacterial Antibiotic

Research Areas:

Infection

Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

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59

Bedaquiline fumarate

59 Cited Publications

Cat. No.: HY-14881A

CAS No.: 845533-86-0

Purity: 99.97%

Synonyms: R403323; TMC207 fumarate; R207910 fumarate

Target:

Bacterial Antibiotic

Research Areas:

Infection

Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.

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53

Streptomycin

53 Cited Publications

Cat. No.: HY-B1906

CAS No.: 57-92-1

Synonyms: Agrept; Agrimycin; Streptomycin A

Category:

Natural Products Microorganisms

Target:

Environmental Pollutants Antibiotic Bacterial

Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .

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40

Levofloxacin hydrochloride

40 Cited Publications

Cat. No.: HY-B0330B

CAS No.: 177325-13-2

Synonyms: (-)-Ofloxacin hydrochloride

Target:

Antibiotic Bacterial DNA/RNA Synthesis Topoisomerase Orthopoxvirus Apoptosis

Research Areas:

Infection Neurological Disease Cancer

Levofloxacin hydrochloride is an orally active antibiotic. Levofloxacin inhibits DNA gyrase and topoisomerase IV activity, inducing Apoptosis. Levofloxacin hydrochloride has antibacterial activity against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride exhibits anticancer activity against lung cancer. Levofloxacin hydrochloride has anti-acnegenic, anxiogenic, and analgesic effects. Levofloxacin hydrochloride shortens sleep duration in mice. Levofloxacin hydrochloride can be used in the research of infectious diseases (such as tuberculosis, chronic periodontitis, bacterial infections associated with stable COPD, and BK viremia) and lung cancer .

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35

Kanamycin

35 Cited Publications

Cat. No.: HY-16566

CAS No.: 59-01-8

Synonyms: Kanamycin A

Category:

Microorganisms Antibiotics Other Antibiotics

Target:

Antibiotic Bacterial

Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .

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35

Kanamycin sulfate

35 Cited Publications

Cat. No.: HY-16566A

CAS No.: 25389-94-0

Synonyms: Kanamycin A sulfate

Category:

Anti-inflammation/Immunoregulatory Disease Research Antibacterial Other Antibiotics Infection Microorganisms Plant Cell Culture Antibiotics Resistance Selection Mammalian Cell Culture Disease Research Fields

Target:

Bacterial Antibiotic

Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .

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25

Complete Freund's adjuvant (CFA)

25 Cited Publications

Cat. No.: HY-153808

CAS No.: 9007-81-2

Target:

Toll-like Receptor (TLR)

Research Areas:

Inflammation/Immunology

Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response .

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23

Moxifloxacin hydrochloride monohydrate

23 Cited Publications

Cat. No.: HY-W353258

CAS No.: 192927-63-2

Synonyms: BAY 12-8039 monohydrate

Moxifloxacin (BAY 12-8039) hydrochloride monohydrate is an orally active bacterial inhibitor that is effective against Streptococcus pneumoniae. Moxifloxacin hydrochloride monohydrate can be used in tuberculosis research .

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18

Cordycepin

18 Cited Publications

Cat. No.: HY-N0262

CAS No.: 73-03-0

Synonyms: 3'-Deoxyadenosine

Category:

Infection Natural Products Microorganisms Disease Research Fields Inflammation/Immunology Cancer

Target:

TNF Receptor MMP Bacterial Autophagy Antibiotic

Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .

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14

Clofazimine

14 Cited Publications

Cat. No.: HY-B1046

CAS No.: 2030-63-9

Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication and inhibiting IL2 (IC₅₀ = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research .

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12

Pretomanid

12 Cited Publications

Cat. No.: HY-10844

CAS No.: 187235-37-6

Purity: 99.97%

Synonyms: PA-824; (S)-PA 824

Target:

Bacterial Antibiotic

Research Areas:

Infection

Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

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10

Incomplete Freund's adjuvant (IFA)

10 Cited Publications

Cat. No.: HY-153808A

Target:

Bacterial

Research Areas:

Inflammation/Immunology Cancer

Incomplete Freund's adjuvant (IFA) (Montanide ISA-51) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund. Incomplete Freund's adjuvant (IFA) does not contain inactivated tuberculosis bacilli and consists of petroleum jelly containing lanolin. Incomplete Freund's adjuvant (IFA) induces high antibody titers and long-lasting effector T cell responses with no long-term effects on collagen disease, tumors, or death. Complete Freund's adjuvant (CFA) (HY-153808) is another type of Freund's Adjuvant that stimulates a stronger immune response .

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9

Telacebec

9 Cited Publications

Cat. No.: HY-101040

CAS No.: 1334719-95-7

Purity: 99.40%

Synonyms: Q203; IAP6

Target:

Bacterial Antibiotic

Research Areas:

Infection

Telacebec (Q203) is a midazopyridine amide compound. Telacebec is active against Mycobacterium tuberculosis H37Rv with an MIC₅₀ of 2.7 nM in culture broth medium.

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8

D-Cycloserine

8 Cited Publications

Cat. No.: HY-B0030

CAS No.: 68-41-7

Category:

Microorganisms Antibiotics Resistance Selection Disease Research Antibacterial Other Antibiotics

Target:

iGluR Bacterial Antibiotic

D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes, with blood-brain barrier permeability. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research .

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7

Chebulinic acid

7 Cited Publications

Cat. No.: HY-N2033

CAS No.: 18942-26-2

Category:

Infection Combretaceae Extract Phenols Polyphenols 500 - Internal Server Error | MedChemExpress

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