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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
2-HBA
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "2-HBA" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
Cat. No.: HY-103667R
CAS No.: 131359-24-5
Research Areas:
2-HBA (Standard) is the analytical standard of 2-HBA (HY-103667). This product is intended for research and analytical applications. 2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.
Cat. No.: HY-P706288
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ¹⁵N-HBA2; ¹⁵N-Hemoglobin A2; ¹⁵N-β-thalassemia marker; Hemoglobin subunit alpha; Alpha-globin; Hemoglobin alpha chain; HBA1; HBA2; Hemoglobin subunit delta; Delta-globin; Hemoglobin delta chain
Species:
Human
Source:
E. coli
Cat. No.: HY-L942
1,623 compounds
Unlike highly conserved orthosteric sites, allosteric sites exhibit low conservation, high hydrophobicity, weak polarity, confined geometry, and dynamic cryptic properties. Rather than rigid keyhole-like cavities, they typically appear as flexible grooves, subunit interface clefts, or shallow depressions formed by protein conformational changes.
Based on the dynamic, hydrophobic, and elongated nature of allosteric pockets, MCE has carried out targeted fragment modification and screening under strict physicochemical criteria: MW 120–280 Da, HBD ≤ 2, HBA ≤ 3, PSA 30–80 Ų, rotatable bonds ≤ 2, cLogP 1–3.5. High 3D diversity was further ensured by PMI analysis, yielding fragments with excellent shape complementarity to allosteric pockets.
This library contains 1,800 structurally diverse, drug-like fragments, this library supports allosteric drug development and pocket optimization. It significantly improves screening hit rates and enables efficient, precise early-stage R&D of allosteric drugs.
Cat. No.: HY-P701277
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD99; MIC2 (Monoclonal Antibody 12E7); Prev. MIC2X; Cell Surface Antigen 12E7; Prev. MIC2Y; Cell Surface Antigen O13; Prev. MIC2; Surface Antigen MIC2; CD99 Antigen; CD99 Molecule; Antigen Identified By Monoclonal Antibodies 12E7, F21 And O13; Protein MIC2; T-Cell Surface Glycoprotein E2; HBA71; E2 Antigen; MSK5X; Antigen Identified By Monoclonal 12E7, Y Homolog; 12E7; CD99 Molecule (Xg Blood Group); Cell Surface Antigen HBA-71
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
