71

71 Publications Verification

Cat. No.: HY-K2014

MCE PEI Transfection Reagent is designed based on 25 kDa PEI. It has high-efficiency, low-toxicity, strong-stability, and is suitable for many cell types, such as HEK-293、HEK-293T、CHO-K1、COS-1、COS-7、NIH/3T3、Sf9、HepG2 and HeLa et, even some hard-to-transfect cells. It can also be applied to large-scale recombinant protein expression and virus production. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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16

PTC-209

16 Cited Publications

Cat. No.: HY-15888

CAS No.: 315704-66-6

Purity: 99.76%

Target:

BMI1 Autophagy

Research Areas:

Cancer

PTC-209 is a specific BMI-1 inhibitor with an IC₅₀ of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment .

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16

PTC-209 hydrobromide

16 Cited Publications

Cat. No.: HY-15888A

CAS No.: 1217022-63-3

Purity: 99.44%

Target:

BMI1 Autophagy

Research Areas:

Cancer

PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC₅₀ of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment .

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3

CFT8634

3 Cited Publications

Cat. No.: HY-145925B

CAS No.: 2704617-96-7

Purity: 98.10%

Target:

PROTACs Epigenetic Reader Domain

Research Areas:

Cancer

CFT8634 is an orally active BRD9 PROTAC degrader with a DC₅₀ of 0.003 μM (HEK293T.166). CFT8634 recruits the CRBN E3 ubiquitin ligase to form a ternary complex, triggering CRBN-catalyzed BRD9 polyubiquitination and 26S proteasome-mediated degradation. CFT8634 induces sustained tumor regression and inhibits tumor growth in mouse models. CFT8634 can be used in research related to synovial sarcoma, SMARCB-1-deficient cancers, acute myeloid leukemia, malignant rhabdoid tumors, and multiple myeloma .

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2

Fenoprofen

2 Cited Publications

Cat. No.: HY-B1456A

CAS No.: 29679-58-1

Synonyms: LILLY-53858

Target:

COX Melanocortin Receptor ERK

Research Areas:

Inflammation/Immunology

Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .

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2

Fenoprofen Calcium hydrate

2 Cited Publications

Cat. No.: HY-B0288B

CAS No.: 71720-56-4

Synonyms: LILLY-53858 Calcium hydrate

Target:

COX Melanocortin Receptor ERK

Research Areas:

Inflammation/Immunology

Fenoprofen (LILLY-53858) Calcium hydrate is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen Calcium hydrate is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen Calcium hydrate also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium hydrate has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .

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2

SSAA09E3

2 Cited Publications

Cat. No.: HY-138102

CAS No.: 52869-18-8

Purity: 98.01%

Target:

SARS-CoV

Research Areas:

Infection

SSAA09E3 is a SARS-CoV entry inhibitor that inhibits SARS/HIV pseudotyped virus entry with an EC₅₀ of 9.7 μM in 293T cells and inhibits SARS-CoV infection of Vero cells with an EC₅₀ of 0.15 μM .

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