51 Results for "

3-IP

" in MedChemExpress (MCE) Product Catalog:
Products (51)

51 Results for "3-IP" in MCE Product Catalog:

82
82 Publications Verification
Cat. No.: HY-B0470
CAS No.: 1405-10-3
Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca 2+ release, MgATP-dependent Ca 2+ uptake, and electrical excitation-evoked skeletal muscle Ca 2+ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer .
loading...
    loading...
11
11 Cited Publications
Cat. No.: HY-F0001
CAS No.: 606-68-8
Synonyms: Disodium NADH
NADH disodium salt (Disodium NADH) is an orally effective reduced coenzyme. NADH disodium salt plays a role in regenerating electron donors during cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle. NADH disodium salt regulates calcium homeostasis by promoting the opening of IP3-gated Ca 2+ channels and inhibiting Ryanodine receptor, and affects mitochondrial function through direct interaction with VDAC. NADH disodium salt is used in cytoprotective studies related to cerebral ischemic injury, neurodegenerative diseases, aging, and signal transduction [3].
loading...
    loading...
11
11 Cited Publications
Cat. No.: HY-103312
CAS No.: 88903-69-9
Purity:  ≥99.0%
Synonyms: (-)-Xestospongin C
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca 2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca 2+ signaling in neuronal and nonneuronal cells [3].
loading...
    loading...
8
8 Cited Publications
Cat. No.: HY-138620
CAS No.: 371924-24-2
Purity:  99.87%
Research Areas:  

Metabolic Disease

MCU-i4 blocks the IP3-dependent mitochondrial Ca 2+-uptake, maintaining the gatekeeping role of their target .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-F0001R
CAS No.: 606-68-8
Synonyms: Disodium NADH (Standard)
NADH disodium salt (Disodium NADH) Standard is the analytical standard of NADH disodium salt (HY-F0001). This product is intended for research and analytical applications. NADH disodium salt (Disodium NADH) is an orally effective reduced coenzyme. NADH disodium salt plays a role in regenerating electron donors during cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle. NADH disodium salt regulates calcium homeostasis by promoting the opening of IP3-gated Ca 2+ channels and inhibiting Ryanodine receptor, and affects mitochondrial function through direct interaction with VDAC. NADH disodium salt is used in cytoprotective studies related to cerebral ischemic injury, neurodegenerative diseases, aging, and signal transduction [3].
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P71288
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SENP2; Sentrin (SUMO1) Specific Peptidase 2; SUMO Specific Peptidase 2; Sentrin/SUMO-Specific Protease SENP2; KIAA1331; SMT3-Specific Isopeptidase 2; SMT3IP2; Sentrin-Specific Protease 2; AXAM2; DKFZp762A2316; SUMO1/Sentrin/SMT3 Specific Peptidase 2; Smt3
Species:  
Human
Source:  
E. coli
loading...
    loading...
Cat. No.: HY-150520
CAS No.: 1404-04-2
Research Areas:  

Infection Cancer

Neomycin, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin is a known phospholipase C (PLC) inhibitor. Neomycin potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin inhibits IP3-mediated Ca 2+ release, MgATP-dependent Ca 2+ uptake, and electrical excitation-evoked skeletal muscle Ca 2+ transients. Neomycin depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin can be used for the research of cancer .
loading...
    loading...
Cat. No.: HY-169396
CAS No.: 2769753-10-6
Synonyms: TL13-87
TAE648 is a target protein ligand of PROTAC SK-3-91 (HY-137341) (Ligand for Target Protein for PROTAC). TAE648 can be used for synthesis PROTAC . TAE648 decreases monolayer-cultured SKOV3ip1 cell viability .
loading...
    loading...
Cat. No.: HY-177285
CAS No.: 1161925-41-2
Target:  

Kinesin ADC Payloads

Research Areas:  

Cancer

NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC50< 0.5 nM. NVP-BQS481 has significant antimitotic and antitumor activity (IC50: 0.0.9 nM for SK-OV-3ip cells). NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .
loading...
    loading...
Cat. No.: HY-122706A
CAS No.: 2967648-66-2
Purity:  99.70%
Target:  

IPK Superfamily

Research Areas:  

Metabolic Disease

IP6K2-IN-2 (Compound 6) is an IP6K2 inhibitor, with IC50 values of 0.58 μM (IP6K2), 0.86 μM (IP6K1) and 3.08 μM (IP6K3). IP6K2-IN-2 can be used in research of obesity .
loading...
    loading...
Cat. No.: HY-W009458
CAS No.: 3318-43-2
Synonyms: 3-IP sodium
3-Indoxyl phosphate (3-IP) is a chromogenic and electrochemical substrate for alkaline phosphatase. Upon enzymatic cleavage by alkaline phosphatase, 3-indoxyl is released and subsequently oxidized to produce water-insoluble indigo, which can be quantified by colorimetric detection at 660 nm as a measure of alkaline phosphatase activity. 3-Indoxyl phosphate can also be converted to water-soluble leucoindigo by reduction of indigo in alkaline solution by sodium dithionite, which can be quantified by colorimetric detection at 415 nm or voltametric detection as a measure of alkaline phosphatase activity.2 3-Indoxyl phosphate has been used in ELISAs.
loading...
    loading...
Cat. No.: HY-W250154
CAS No.: 104809-32-7
β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally effective reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role in regenerating electron donors during cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle. β-Nicotinamide adenine dinucleotide reduced dipotassium regulates calcium homeostasis by promoting the opening of IP3-gated Ca 2+ channels and inhibiting Ryanodine receptor, and affects mitochondrial function through direct interaction with VDAC. β-Nicotinamide adenine dinucleotide reduced dipotassium is used in cytoprotective studies related to cerebral ischemic injury, neurodegenerative diseases, aging, and signal transduction [3].
loading...
    loading...
Cat. No.: HY-177079S
CAS No.: 2759134-55-7
Dazodeunetant (Example 56) is a nitrogen-containing fused ring derivative. Dazodeunetant is an inhibitor of neurokinin (NK). Dazodeunetant has an IC50 0f 75.99 nM against NK3R in HEK293-NK3 (IP1). Dazodeunetant can be studied in research for menopausal hot flashes .
loading...
    loading...
Cat. No.: HY-RS11313
Research Areas:  

Others

PSMC3IP Human Pre-designed siRNA Set A contains three designed siRNAs for PSMC3IP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS11562
Research Areas:  

Others

RAB3IP Human Pre-designed siRNA Set A contains three designed siRNAs for RAB3IP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS06549
Research Areas:  

Others

IER3IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for IER3IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS10535
Research Areas:  

Others

PIK3IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIK3IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS14970
Research Areas:  

Others

TRAF3IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAF3IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS14971
Research Areas:  

Others

TRAF3IP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAF3IP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS14972
Research Areas:  

Others

TRAF3IP3 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAF3IP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...