117

Nirmatrelvir

117 Publications Verification

Cat. No.: HY-138687

CAS No.: 2628280-40-8

Purity: 99.74%

Synonyms: PF-07321332

Target:

SARS-CoV

Research Areas:

Infection Inflammation/Immunology

Nirmatrelvir (PF-07321332) is a potent and orally active SARS-CoV 3C-like protease (3CL ^PRO) inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research .

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46

Asunaprevir

46 Cited Publications

Cat. No.: HY-14434

CAS No.: 630420-16-5

Purity: 99.84%

Synonyms: BMS-650032

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Asunaprevir (BMS-650032) is a potent and orally bioavailable hepatitis C virus (HCV) NS3 protease inhibitor, with IC₅₀ of 0.2 nM-3.5 nM . Asunaprevir inhibits SARS-CoV-2 3CL ^pro activity .

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44

Telaprevir

44 Cited Publications

Cat. No.: HY-10235

CAS No.: 402957-28-2

Purity: 99.54%

Synonyms: VX-950

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (K_i) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide ^[3]. Telaprevir inhibits SARS-CoV-2 3CL ^pro activity .

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34

Boceprevir

34 Cited Publications

Cat. No.: HY-10237

CAS No.: 394730-60-0

Purity: 98.52%

Synonyms: EBP 520; SCH 503034

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a K_i of 14 nM in both enzyme assay and an EC₉₀ of 350 nM in cell-based replicon assay ^[3] . Boceprevir inhibits SARS-CoV-2 3CL ^pro activity .

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33

Ritonavir

33 Cited Publications

Cat. No.: HY-90001

CAS No.: 155213-67-5

Synonyms: ABT 538; RTV

Target:

HIV Protease HIV SARS-CoV Apoptosis

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.61 μM. Ritonavir (ABT 538) can penetrate the blood brain barrier (BBB) ^[3] .

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31

Ledipasvir

31 Cited Publications

Cat. No.: HY-15602

CAS No.: 1256388-51-8

Purity: 99.69%

Synonyms: GS-5885

Target:

HCV SARS-CoV

Research Areas:

Infection

Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC₅₀s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.62 μM ^[3].

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30

Grazoprevir

30 Cited Publications

Cat. No.: HY-15298

CAS No.: 1350514-68-9

Purity: 99.99%

Synonyms: MK-5172

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir inhibits SARS-CoV-2 3CL ^pro activity ^[3].

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30

Grazoprevir potassium salt

30 Cited Publications

Cat. No.: HY-15298A

CAS No.: 1206524-86-8

Purity: 99.63%

Synonyms: MK-5172 potassium salt

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir potassium salt inhibits SARS-CoV-2 3CL ^pro activity ^[3].

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30

Grazoprevir hydrate

30 Cited Publications

Cat. No.: HY-15298B

CAS No.: 1350462-55-3

Purity: 99.99%

Synonyms: MK-5172 hydrate

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir hydrate inhibits SARS-CoV-2 3CL ^pro activity ^[3].

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25

Bardoxolone

25 Cited Publications

Cat. No.: HY-14909

CAS No.: 218600-44-3

Purity: 99.50%

Synonyms: CDDO; RTA 401

Target:

Keap1-Nrf2 NF-κB SARS-CoV Apoptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase Necroptosis

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Bardoxolone (CDDO; RTA 401) is a Nrf2 activator. Bardoxolone shows anti-SARS-CoV-2 3CLpro with IC50 of 27.99 μM. Bardoxolone activates the Nrf2 pathway and inhibits the NF-κB pathway. Bardoxolone can induce cells differentiation, apoptosis and shows antiproliferative activity against cancer cells. Bardoxolone can increase ROS and decrease intracellular GSH levels. Bardoxolone inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis. Bardoxolone can be used for the research of cancer, inflammation and infection, such as SARS-CoV infection and glioblastoma ^[3].

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21

Lopinavir

21 Cited Publications

Cat. No.: HY-14588

CAS No.: 192725-17-0

Purity: 99.71%

Synonyms: ABT-378

Target:

HIV HIV Protease SARS-CoV

Research Areas:

Infection Neurological Disease Cancer

Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM ^[3].

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