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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
3R tau
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "3R tau" in MCE Product Catalog:
Cat. No.: HY-174215
CAS No.: 3063511-09-8
Target:
Research Areas:
TAU-IN-3 (Compound 2) is an orally active TAU inhibitor. TAU-IN-3 inhibits the expression of MAPT exon 10 DDPAC mutant gene in HeLa cells (IC50: 0.6 µM). TAU-IN-3 reduces the 4R/3R MAPT mRNA ratio in HeLa cells transfected with WT or DDPAC minigenes. TAU-IN-3 inhibits the insertion of endogenous MAPT exon 10 and the production of 4R tau protein in cells. TAU-IN-3 modulates tau splicing in htau mice and improves the associated behavioral phenotypes. TAU-IN-3 can be used to study neurodegenerative diseases .
Cat. No.: HY-P991704
CAS No.: 3031519-40-8
Synonyms: PRX-005
Target:
Research Areas:
Cat. No.: HY-159941
CAS No.: 2200453-71-8
Target:
Research Areas:
tau-0N4R-IN-1 (Compound 6T) is an BBB-penetrable inhibitor of tau 0N4R oligomerization. tau-0N4R-IN-1 effectively inhibits the fibrosis of tau 0N4R, 2N3R, and 2N4R, exhibits an anti-seeding effect on tau in vitro, reduces the oligomerization of α-syn dose-dependently, and prevents formation of α-syn inclusions. tau-0N4R-IN-1 is stable in mouse microsomes and reduces Aβ plaques in brain tissues from AD patients. tau-0N4R-IN-1 has good pharmacokinetic properties in mice .
Cat. No.: HY-189715
CAS No.: 3025238-91-6
Target:
Research Areas:
PTC-003 is an orally active and blood-brain barrier-penetrant MAPT pre-mRNA splicing modulator. PTC-003 promotes skipping of exon 10 of the MAPT gene, shifting the protein isoform balance from toxic 4R-tau toward 3R-tau. PTC-003 reduces the accumulation of hyperphosphorylated tau, oligomeric tau, and insoluble tau protein. PTC-003 protects neurons from glutamate-induced neuronal stress injury, and in humanized MAPT gene-replaced N279K mice, it corrects the 3R/4R-tau isoform ratio in brain tissue and reduces the level of pathogenic pTau T231. PTC-003 can be used in research related to neurodegenerative diseases .
Cat. No.: HY-162812
Research Areas:
H3R antagonist 4 (compound 11L) was a dual inhibitor of cholinesterase and histamine receptor (H3R), with corresponding IC50 of 7.04 μM (eeAChE), 9.73 μM (hAChE)(reversible) and 1.09 nM (H3R) , respectively. H3R antagonist 4 inhibited the aggregation of Aβ1-42 induced by itself and Cu 2+ (95.48% and 88.63%) , and degraded the Aβ1-42 fibrils induced by itself and Cu 2+ (80.16% and 89.30%) . H3R antagonist 4 chelate biometals such as Cu 2+, Zn 2+, Al 3+, and Fe 2+. H3R antagonist 4 significantly reduced tau protein hyperphosphorylation induced by Aβ1-42 and inhibited RSL-3-induced apoptosis and ferroptosis in PC12 cells. H3R antagonist 4 had the best blood-brain barrier permeability and intestinal absorption in hCMEC/D3 and hPepT1-MDCK cells.H3R antagonist 4 ameliorates learning and memory impairment in a mouse model of Alzheimer's disease induced by scopolamine (HY-N0296) .
Cat. No.: HY-189713
CAS No.: 2650573-17-2
Target:
Research Areas:
PTC-553 is a microtubule-associated protein tau (MAPT) mRNA splicing modulator. PTC-553 promotes exon 10 exclusion by modulating MAPT pre-mRNA splicing, corrects the 4R/3R tau isoform imbalance, thereby reducing the pathological accumulation of 4R tau protein and alleviating neurotoxicity. PTC-553 can be used for research on frontotemporal dementia and tauopathies .
Cat. No.: HY-P73618
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
Cat. No.: HY-P73618A
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
Cat. No.: HY-P704906
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
