10271 Results for "

430-Cavity Targeting

" in MedChemExpress (MCE) Product Catalog:

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843

Dorsomorphin dihydrochloride

843 Publications Verification

Cat. No.: HY-13418

CAS No.: 1219168-18-9

Purity: 99.7%

Synonyms: BML-275 dihydrochloride; Compound C dihydrochloride

Target:

Organoid AMPK TGF-β Receptor Autophagy

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a K_i of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).

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226

MHY1485

226 Cited Publications

Cat. No.: HY-B0795

CAS No.: 326914-06-1

Target:

mTOR Autophagy

Research Areas:

Cancer

MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR. MHY1485 inhibits autophagy by suppression of fusion between autophagosomes and lysosomes .

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168

Mitoquinone mesylate

168 Cited Publications

Cat. No.: HY-100116A

CAS No.: 845959-50-4

Purity: 99.09%

Synonyms: MitoQ mesylate; MitoQ10 mesylate

Target:

Reactive Oxygen Species (ROS)

Research Areas:

Metabolic Disease Cancer

Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage .

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132

C-176

132 Cited Publications

Cat. No.: HY-112906

CAS No.: 314054-00-7

Purity: 99.45%

Target:

STING

Research Areas:

Inflammation/Immunology

C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING .

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117

Nirmatrelvir

117 Cited Publications

Cat. No.: HY-138687

CAS No.: 2628280-40-8

Purity: 99.74%

Synonyms: PF-07321332

Target:

SARS-CoV

Research Areas:

Infection Inflammation/Immunology

Nirmatrelvir (PF-07321332) is a potent and orally active SARS-CoV 3C-like protease (3CL ^PRO) inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research .

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114

Sunitinib

114 Cited Publications

Cat. No.: HY-10255A

CAS No.: 557795-19-4

Purity: 99.04%

Synonyms: SU 11248

Target:

VEGFR PDGFR IRE1 Mitophagy Autophagy Apoptosis

Research Areas:

Cancer

Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC₅₀s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation .

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114

Sunitinib Malate

114 Cited Publications

Cat. No.: HY-10255

CAS No.: 341031-54-7

Purity: 99.86%

Synonyms: SU 11248 Malate

Target:

PDGFR VEGFR IRE1 Mitophagy Autophagy Apoptosis

Research Areas:

Infection Inflammation/Immunology Cancer

Sunitinib (SU 11248) Malat is a multi-targeted receptor tyrosine kinase inhibitor with IC₅₀s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib Malat, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation .

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114

Sunitinib glucuronate

114 Cited Publications

Cat. No.: HY-10255C

CAS No.: 1818285-48-1

Synonyms: SU 11248 glucuronate

Target:

PDGFR VEGFR IRE1 Mitophagy Autophagy Apoptosis

Research Areas:

Cancer

Sunitinib (SU 11248) glucuronate is a multi-targeted receptor tyrosine kinase inhibitor with IC₅₀s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib glucuronate, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation .

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110

3-TYP

110 Cited Publications

Cat. No.: HY-108331

CAS No.: 120241-79-4

Purity: 99.96%

Target:

Sirtuin Methionine Adenosyltransferase (MAT) Indoleamine 2,3-Dioxygenase (IDO)

Research Areas:

Cancer

3-TYP is an inhibitor of SIRT3 (IC₅₀of 38 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases .

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106

Lenvatinib

106 Cited Publications

Cat. No.: HY-10981

CAS No.: 417716-92-8

Purity: 99.75%

Synonyms: E7080; MK-7902

Target:

VEGFR FGFR PDGFR c-Kit RET

Research Areas:

Cancer

Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities .

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106

Lenvatinib mesylate

106 Cited Publications

Cat. No.: HY-10981A

CAS No.: 857890-39-2

Purity: 99.86%

Synonyms: E7080 mesylate; MK-7902 mesylate

Target:

VEGFR FGFR PDGFR RET c-Kit

Research Areas:

Cancer

Lenvatinib mesylate (E7080 mesylate), an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities .

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100

Regorafenib Hydrochloride

100 Cited Publications

Cat. No.: HY-13308

CAS No.: 835621-07-3

Purity: 99.58%

Synonyms: BAY 73-4506 hydrochloride

Target:

VEGFR Autophagy PDGFR Raf RET

Research Areas:

Cancer

Regorafenib Hydrochloride (BAY 73-4506 hydrochloride) is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC₅₀s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively .

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IWR-1

72 Cited Publications

Cat. No.: HY-12238

CAS No.: 1127442-82-3

Purity: 99.60%

Synonyms: endo-IWR 1; IWR-1-endo

Target:

Organoid Wnt

Research Areas:

Inflammation/Immunology Cancer

IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin (IC₅₀ = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .

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