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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
4R tau
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "4R tau" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P70589
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P71102
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
Cat. No.: HY-174215
CAS No.: 3063511-09-8
Target:
Research Areas:
TAU-IN-3 (Compound 2) is an orally active TAU inhibitor. TAU-IN-3 inhibits the expression of MAPT exon 10 DDPAC mutant gene in HeLa cells (IC50: 0.6 µM). TAU-IN-3 reduces the 4R/3R MAPT mRNA ratio in HeLa cells transfected with WT or DDPAC minigenes. TAU-IN-3 inhibits the insertion of endogenous MAPT exon 10 and the production of 4R tau protein in cells. TAU-IN-3 modulates tau splicing in htau mice and improves the associated behavioral phenotypes. TAU-IN-3 can be used to study neurodegenerative diseases .
Cat. No.: HY-175840
CAS No.: 3118812-61-3
Target:
Research Areas:
TAU-IN-5 (compound 13) is a TAU protein inhibitor with an EC50 of 0.81 μM. TAU-IN-5 inhibits the formation of tau (2N4R isoform) oligomers and reduces the formation of tau dimers. TAU-IN-5 can be used in the study of Alzheimer's disease (AD) and Parkinson's disease (PD) .
Cat. No.: HY-163145
CAS No.: 3095291-54-3
Target:
Research Areas:
α-Synuclein inhibitor 11 (compound 1) is a selective α-synuclein (α-syn) oligomer formation inhibitor. α-Synuclein inhibitor 11 does not inhibits tau 4R (isoforms 0N4R, 2N4R) or p-tau (isoform 1N4R). α-Synuclein inhibitor 11 can be used for Parkinson's disease (PD) research .
Cat. No.: HY-P991704
CAS No.: 3031519-40-8
Synonyms: PRX-005
Target:
Research Areas:
Cat. No.: HY-159941
CAS No.: 2200453-71-8
Target:
Research Areas:
tau-0N4R-IN-1 (Compound 6T) is an BBB-penetrable inhibitor of tau 0N4R oligomerization. tau-0N4R-IN-1 effectively inhibits the fibrosis of tau 0N4R, 2N3R, and 2N4R, exhibits an anti-seeding effect on tau in vitro, reduces the oligomerization of α-syn dose-dependently, and prevents formation of α-syn inclusions. tau-0N4R-IN-1 is stable in mouse microsomes and reduces Aβ plaques in brain tissues from AD patients. tau-0N4R-IN-1 has good pharmacokinetic properties in mice .
Cat. No.: HY-173049
Target:
Research Areas:
2N4R Tau/α-Syn against-1 (Compound 4d) targets α-synuclein and tau protein, inhibits the fibrillation and oligomer formation of α-synuclein and tau proteins, exhibits disaggregation activity on Aβ fibers. 2N4R Tau/α-Syn against-1 can be used in research of Parkinson's disease and Alzheimer's disease .
Cat. No.: HY-189713
CAS No.: 2650573-17-2
Target:
Research Areas:
PTC-553 is a microtubule-associated protein tau (MAPT) mRNA splicing modulator. PTC-553 promotes exon 10 exclusion by modulating MAPT pre-mRNA splicing, corrects the 4R/3R tau isoform imbalance, thereby reducing the pathological accumulation of 4R tau protein and alleviating neurotoxicity. PTC-553 can be used for research on frontotemporal dementia and tauopathies .
Cat. No.: HY-169197
CAS No.: 2276762-07-1
Target:
Research Areas:
D-688 is an inhibitor of Tau and Aβ. D-688 can reverse Aβ1–42-induced toxicity in SH-SH5Y cells and has significant neuroprotective properties. D-688 can improve the survival rate of Drosophila melanogaster expressing the human tau protein isoform (2N4R) .
Cat. No.: HY-189715
CAS No.: 3025238-91-6
Target:
Research Areas:
PTC-003 is an orally active and blood-brain barrier-penetrant MAPT pre-mRNA splicing modulator. PTC-003 promotes skipping of exon 10 of the MAPT gene, shifting the protein isoform balance from toxic 4R-tau toward 3R-tau. PTC-003 reduces the accumulation of hyperphosphorylated tau, oligomeric tau, and insoluble tau protein. PTC-003 protects neurons from glutamate-induced neuronal stress injury, and in humanized MAPT gene-replaced N279K mice, it corrects the 3R/4R-tau isoform ratio in brain tissue and reduces the level of pathogenic pTau T231. PTC-003 can be used in research related to neurodegenerative diseases .
Cat. No.: HY-P704914
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
Cat. No.: HY-P700421
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
HEK293
Cat. No.: HY-P704324
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
Cat. No.: HY-P704904
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
Cat. No.: HY-P704905
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
Cat. No.: HY-P704912
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
Cat. No.: HY-P704913
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
Cat. No.: HY-P704909
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
Cat. No.: HY-P704911
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; tau-Derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-tau; PPP1R103; MGC138549; tau-PHF6; FLJ31424; FTDP-17; PHF-tau; tau-40; Mic
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
