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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
4R-Tau
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "4R-Tau" in MCE Product Catalog:
Cat. No.: HY-174215
CAS No.: 3063511-09-8
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TAU-IN-3 (Compound 2) is an orally active TAU inhibitor. TAU-IN-3 inhibits the expression of MAPT exon 10 DDPAC mutant gene in HeLa cells (IC50: 0.6 µM). TAU-IN-3 reduces the 4R/3R MAPT mRNA ratio in HeLa cells transfected with WT or DDPAC minigenes. TAU-IN-3 inhibits the insertion of endogenous MAPT exon 10 and the production of 4R tau protein in cells. TAU-IN-3 modulates tau splicing in htau mice and improves the associated behavioral phenotypes. TAU-IN-3 can be used to study neurodegenerative diseases .
Cat. No.: HY-P991704
CAS No.: 3031519-40-8
Synonyms: PRX-005
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Cat. No.: HY-189715
CAS No.: 3025238-91-6
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PTC-003 is an orally active and blood-brain barrier-penetrant MAPT pre-mRNA splicing modulator. PTC-003 promotes skipping of exon 10 of the MAPT gene, shifting the protein isoform balance from toxic 4R-tau toward 3R-tau. PTC-003 reduces the accumulation of hyperphosphorylated tau, oligomeric tau, and insoluble tau protein. PTC-003 protects neurons from glutamate-induced neuronal stress injury, and in humanized MAPT gene-replaced N279K mice, it corrects the 3R/4R-tau isoform ratio in brain tissue and reduces the level of pathogenic pTau T231. PTC-003 can be used in research related to neurodegenerative diseases .
Cat. No.: HY-189713
CAS No.: 2650573-17-2
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PTC-553 is a microtubule-associated protein tau (MAPT) mRNA splicing modulator. PTC-553 promotes exon 10 exclusion by modulating MAPT pre-mRNA splicing, corrects the 4R/3R tau isoform imbalance, thereby reducing the pathological accumulation of 4R tau protein and alleviating neurotoxicity. PTC-553 can be used for research on frontotemporal dementia and tauopathies .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
