19

Paroxetine

19 Publications Verification

Cat. No.: HY-122272

CAS No.: 61869-08-7

Purity: 99.92%

Synonyms: BRL29060

Target:

Cytochrome P450 5-HT Receptor NO Synthase Apoptosis Serotonin Transporter Estrogen Receptor/ERR

Research Areas:

Neurological Disease Cancer

Paroxetine (BRL29060) is an orally active and selective serotonin reuptake inhibitor (SSRI) and apoptosis inducer with blood-brain barrier permeability. Paroxetine inhibits nitric oxide synthase and CYP2D6, induces desensitization of 5-HT1A/1B/1D autoreceptors, downregulates 5-HT2 receptors, and promotes the production of inflammatory cytokines. Paroxetine is a weak norepinephrine (NE) uptake inhibitor and possesses antitumor activity. Paroxetine is widely used in research concerning depression, obsessive-compulsive disorder, panic disorder, social phobia, generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, hot flashes, and related conditions .

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19

Paroxetine hydrochloride

19 Publications Verification

Cat. No.: HY-B0492

CAS No.: 78246-49-8

Synonyms: BRL29060 hydrochloride; BRL29060A

Target:

Cytochrome P450 5-HT Receptor NO Synthase Apoptosis Serotonin Transporter Estrogen Receptor/ERR

Research Areas:

Neurological Disease Cancer

Paroxetine (BRL29060) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI) and apoptosis inducer with blood-brain barrier permeability. Paroxetine hydrochloride inhibits nitric oxide synthase and CYP2D6, induces desensitization of 5-HT1A/1B/1D autoreceptors, downregulates 5-HT2 receptors, and promotes the production of inflammatory cytokines. Paroxetine hydrochloride is a weak norepinephrine (NE) uptake inhibitor and possesses antitumor activity. Paroxetine hydrochloride is widely used in research concerning depression, obsessive-compulsive disorder, panic disorder, social phobia, generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, hot flashes, and related conditions .

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11

Paroxetine hydrochloride hemihydrate

11 Cited Publications

Cat. No.: HY-B0492A

CAS No.: 110429-35-1

Synonyms: BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate

Target:

Autophagy Serotonin Transporter G Protein-coupled Receptor Kinase (GRK)

Research Areas:

Neurological Disease Cancer

Paroxetine (BRL29060) hydrochloride hemihydrate is an orally active and selective serotonin reuptake inhibitor (SSRI) and apoptosis inducer with blood-brain barrier permeability. Paroxetine hydrochloride hemihydrate inhibits nitric oxide synthase and CYP2D6, induces desensitization of 5-HT1A/1B/1D autoreceptors, downregulates 5-HT2 receptors, and promotes the production of inflammatory cytokines. Paroxetine hydrochloride hemihydrate is a weak norepinephrine (NE) uptake inhibitor and possesses antitumor activity. Paroxetine hydrochloride hemihydrate is widely used in research concerning depression, obsessive-compulsive disorder, panic disorder, social phobia, generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, hot flashes, and related conditions .

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10

Citalopram hydrobromide

10 Cited Publications

Cat. No.: HY-B1287

CAS No.: 59729-32-7

Synonyms: (±)-Citalopram hydrobromide; Lu 10-171

Target:

Serotonin Transporter Autophagy

Research Areas:

Neurological Disease Cancer

Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI), with blood-brain barrier permeability. Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC₅₀ of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC₅₀ of 14 nM. Antidepressant effect .

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8

Clorgyline hydrochloride

8 Cited Publications

Cat. No.: HY-14197A

CAS No.: 17780-75-5

Purity: 99.92%

Synonyms: M&B 9302 hydrochloride

Target:

Monoamine Oxidase 5-HT Receptor Bcl-2 Family

Clorgyline hydrochloride (M&B 9302 hydrochloride) is a selective, irreversible monoamine oxidase A (MAO-A) inhibitor that can cross the blood-brain barrier and exhibits activity against the 5-HT Receptor at very high doses. Clorgyline hydrochloride regulates monoamine neurotransmitter levels, the release of dopamine and acetylcholine, the uptake and effects of Tyramine (HY-W007606), noradrenergic function, circadian locomotor activity rhythms, feeding behavior, and body weight. Clorgyline hydrochloride induces tumor-suppressive transcriptional programs, secretory differentiation, androgen signaling regulation, Bcl-2 expression, and radioprotective effects in non-malignant cells. Clorgyline hydrochloride is used in the research of high-grade prostate cancer, Huntington's disease, major affective disorder, radiation-induced normal tissue toxicity, and obesity .

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8

Clorgyline

8 Cited Publications

Cat. No.: HY-14197

CAS No.: 17780-72-2

Purity: 99.76%

Synonyms: M&B 9302

Target:

Monoamine Oxidase 5-HT Receptor Bcl-2 Family

Research Areas:

Neurological Disease Metabolic Disease Cancer

Clorgyline (M&B 9302) is a selective, irreversible monoamine oxidase A (MAO-A) inhibitor that can cross the blood-brain barrier and exhibits activity against the 5-HT Receptor at very high doses. Clorgyline regulates monoamine neurotransmitter levels, the release of dopamine and acetylcholine, the uptake and effects of Tyramine (HY-W007606), noradrenergic function, circadian locomotor activity rhythms, feeding behavior, and body weight. Clorgyline induces tumor-suppressive transcriptional programs, secretory differentiation, androgen signaling regulation, Bcl-2 expression, and radioprotective effects in non-malignant cells. Clorgyline is used in the research of high-grade prostate cancer, Huntington's disease, major affective disorder, radiation-induced normal tissue toxicity, and obesity .

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6

Nomifensine

6 Cited Publications

Cat. No.: HY-B1110

CAS No.: 24526-64-5

Synonyms: (±)-Nomifensine; Nomifensin

Target:

Dopamine Receptor Adrenergic Receptor

Research Areas:

Neurological Disease

Nomifensine ((±)-Nomifensine) is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine has antidepressant and analgesic effects. Nomifensine is used in neurodegenerative diseases, compound addiction, and pain research .

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6

Nomifensine maleate

6 Cited Publications

Cat. No.: HY-B1110A

CAS No.: 32795-47-4

Synonyms: (±)-Nomifensine maleate; Nomifensin maleate

Target:

Dopamine Receptor Adrenergic Receptor

Research Areas:

Neurological Disease

Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .

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