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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
6-Hz model
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "6-Hz model" in MCE Product Catalog:
Cat. No.: HY-155238
CAS No.: 1520073-91-9
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E2730 is a noncompetitive but selective inhibitor of gamma-aminobutyric acid (GABA) transporter 1 (GAT1) with orally available and antiepileptic activity. E2730-mediated GAT1 inhibition is positively correlated with environmental GABA levels and selectively inhibits GAT1-mediated GABA uptake. E2730 (5-50 mg/kg; po) in rat amygdala ignition model, and in mouse cornea ignition (5-50 mg/kg), drug resistance 6Hz-44mA has demonstrated in vivo efficacy in models of psychomotor epilepsy (5-50 mg/kg), fragile X syndrome (2.5-300 mg/kg), and Dravet syndrome (10 mg/kg, 20 mg/kg) .
Cat. No.: HY-145761
CAS No.: 2097604-91-4
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Research Areas:
AMPA-IN-1 is an orally active AMPA receptor inhibitor with an IC50 of 17.70 nM. AMPA-IN-1 inhibits AMPA-induced intracellular calcium influx in rat embryonic cerebral cortical neurons. AMPA-IN-1 exhibits anticonvulsant-related activity in the mouse 6 Hz psychomotor seizure model. AMPA-IN-1 can be used for research on AMPA-mediated diseases, such as epilepsy .
Cat. No.: HY-177302
CAS No.: 1127498-73-0
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mGluR2 modulator 6 (Compound 25-a) is a mGluR2 modulator. mGluR2 modulator 6 has anticonvulsant activity in the 6Hz epilepsy model, and the effect is better when combined with Levetiracetam (HY-B0106). mGluR2 modulator 6 can be used in the research of epilepsy .
Cat. No.: HY-114300
CAS No.: 1226855-28-2
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Research Areas:
DSP-0565 (compound 17a) is a strong, broad-spectrum anti-epileptic agent (AED) candidate with unique GABAergic function. DSP-0565 shows anti-convulsant activity in various models (scPTZ, MES, 6 Hz and amygdala kindling) with good safety margin .
Cat. No.: HY-N18014
CAS No.: 102101-05-3
Synonyms: NRG-DM
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
