123 Results for "

6-Methyl

" in MedChemExpress (MCE) Product Catalog:
Products (123)

123 Results for "6-Methyl" in MCE Product Catalog:

21
21 Publications Verification
Cat. No.: HY-N0560
CAS No.: 480-11-5
Synonyms: Baicalein 6-Methyl ether; 6-Methoxybaicalein
Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-134124
CAS No.: 92614-59-0
Purity:  95.8%
Research Areas:  

Metabolic Disease

Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P1108
CAS No.: 681260-70-8
Target:  

CRFR

Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 [6] .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P1108A
Target:  

CRFR

Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 [6] .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-A0248A
CAS No.: 4135-11-9
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .
loading...
    loading...
Cat. No.: HY-W011725
CAS No.: 2002-35-9
Synonyms: m6dA
N-6-Methyl-2-deoxyadenosine (m6dA) is an adenine nucleoside analogue. N-6-Methyl-2-deoxyadenosine targets nuclear processes and DNA replication machineries including WER, SATB1, TFAM, Jumu, SSBP1, DNA polymerase η and phage polymerase Gp90 exo −. N-6-Methyl-2-deoxyadenosine acts as a multifunctional epigenetic regulator that modulates transcription, DNA damage response, cell cycle, transposon silencing, stress adaptation, epigenetic crosstalk, and nucleosome organization in both prokaryotes and eukaryotes. N-6-Methyl-2-deoxyadenosine regulates mitochondrial epigenetic inheritance and is required for fear extinction memory in mice. N-6-Methyl-2-deoxyadenosine exhibits dysregulated levels in cancers. N-6-Methyl-2-deoxyadenosine can be used for the research of glioblastoma, triple negative breast cancer, and conditioned fear (fear extinction impairment) .
loading...
    loading...
Cat. No.: HY-W390763B
CAS No.: 2832734-19-5
Target:  

Drug Intermediate

Research Areas:  

Others

(S)-6-Methyl-1,4-oxazepan-6-ol hydrochloride is a drug intermediate for synthesis of various active compounds.
loading...
    loading...
Cat. No.: HY-W010435
CAS No.: 110-93-0
Synonyms: 6-Methyl-5-hepten-2-one
Sulcatone (6-Methyl-5-hepten-2-one) is a plant-derived volatile organic compound with activities such as insecticidal, antifungal, and blood pressure-lowering effects. Sulcatone also serves as an insect pheromone and an endogenous metabolite, which can be found in feces. Changes in Sulcatone levels can be used for the auxiliary diagnosis of ulcerative colitis .
loading...
    loading...
Cat. No.: HY-141274
CAS No.: 58884-35-8
Purity:  95.16%
Target:  

PROTAC Linkers

Research Areas:  

Cancer

4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
loading...
    loading...
Cat. No.: HY-B1233
CAS No.: 543-82-8
Synonyms: 2-Amino-6-Methylheptane; 1,5-DiMethylhexylamine; 6-Methyl-2-heptylamine
Octodrine (2-Amino-6-methylheptane) is a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Octodrine is found to increase the pain threshold, cardiac rate (positive chronotropic effect) and myocardial contractility (positive inotropic effect) .
loading...
    loading...
Cat. No.: HY-Y1634
CAS No.: 675-10-5
Target:  

Drug Intermediate

Research Areas:  

Infection Cancer

4-Hydroxy-6-methyl-2-pyrone is an intermediate. 4-Hydroxy-6-methyl-2-pyrone can be used for the synthesis of Hispidin (HY-100618) and antibacterial agents. 4-Hydroxy-6-methyl-2-pyrone can be used for research on bacterial infections, fungal infections, pancreatic adenocarcinoma, squamous cell carcinoma, and tuberculosis .
loading...
    loading...
Cat. No.: HY-115749
CAS No.: 24404-90-8
Purity:  99.93%
Synonyms: 6′-Methoxyluciferin
Target:  

Fluorescent Dye

Research Areas:  

Others

D-Luciferin 6′-methyl ether (6′-Methoxyluciferin; compound 19a) is a potent luciferase from the North American firefly Photinus pyralis (PpyLuc) inhibitor with an IC50 of 0.1 µM. D-Luciferin 6′-methyl ether, a D-luciferin analog, shows non-specific interactions at ATP- and luciferin-binding sites of the PpyLuc active site .
loading...
    loading...
Cat. No.: HY-Y0455
CAS No.: 1824-81-3
Synonyms: 2-Amino-6-picoline
Research Areas:  

Others

6-Methyl-2-pyridinamine (2-Amino-6-picoline) is a metal coordination ligand. 6-Methyl-2-pyridinamine is promising for research of is promising for research of metal-organic frameworks (MOFs) and functional coordination polymers .
loading...
    loading...
Cat. No.: HY-138582
CAS No.: 105931-58-6
Purity:  99.83%
N6-Methyl-dA phosphoramidite can be used in the synthesis of oligodeoxyribonucleotides .
loading...
    loading...
Cat. No.: HY-134393
CAS No.: 3130-39-0
Synonyms: N6-Methyl-ATP
Target:  

GSK-3

Research Areas:  

Neurological Disease

6-Me-ATP (N6-Methyl-ATP) is an N 6-modified ATP derivative. 6-Me-ATP exhibits excellent binding affinity for GSK3 and acts as a phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptides. 6-Me-ATP is applicable to research related to Alzheimer's disease .
loading...
    loading...
Cat. No.: HY-134393B
Purity:  99.89%
Synonyms: N6-Methyl-ATP trisodium solution (100 mM)
6-Me-ATP (N6-Methyl-ATP) trisodium solution (100 mM) is a N 6-modified ATP derivative. 6-Me-ATP trisodium shows excellent binding affinity to GSK3, serving as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptide .
loading...
    loading...
Cat. No.: HY-W100249
CAS No.: 136468-19-4
Synonyms: 5-Methoxy-6-Methyl-2-aminoindan
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

MMAI is a selective serotonin releaser that can be used in the research of mental illnesses .
loading...
    loading...
Cat. No.: HY-W347492
CAS No.: 964-21-6
Synonyms: O6-Methyl-2′-deoxyguanosine
Research Areas:  

Cancer

O6-Methyldeoxy guanosine; DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
loading...
    loading...
Cat. No.: HY-164793
CAS No.: 733806-89-8
Research Areas:  

Infection

TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P450s. TGFBR1-IN-2 contains the pyridyl-6-methyl moiety necessary for Mycobacterium tuberculosis inhibition and has potent inhibitory activity against non-replicating and persistent Mycobacterium tuberculosis .
loading...
    loading...
Cat. No.: HY-W714356
CAS No.: 1354782-02-7
N-6-Methyl-2-deoxyadenosine-d3 is the deuterium labeled N-6-Methyl-2-deoxyadenosine (HY-W011725). N-6-Methyl-2-deoxyadenosine is an adenine nucleoside analogue .
loading...
    loading...