2 Results for "

8RK64

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "8RK64" in MCE Product Catalog:

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Cat. No.: HY-148254
CAS No.: 2705841-52-5
Purity:  99.78%
Target:  

Deubiquitinase

Research Areas:  

Others

8RK64 is a UCHL1 inhibitor that covalently binds the active-site cysteine residue to form an isothiourea adduct, with selectivity over UCHL3, UCHL5, and other cysteine DUBs. 8RK64 inhibits human UCHL1 with an IC50 of 0.32 μM. 8RK64 is an azide-containing precursor usable as a two-step activity-based probe via click chemistry. 8RK64 can be used for the research of Parkinson's disease .
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Cat. No.: HY-D1726
CAS No.: 2705841-53-6
8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59 .
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