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51 Results for "

A375

" in MedChemExpress (MCE) Product Catalog:

Products (51)

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Ulixertinib

57 Publications Verification

Cat. No.: HY-15816

CAS No.: 869886-67-9

Purity: 99.95%

Synonyms: BVD-523; VRT752271

Target:

ERK

Research Areas:

Cancer

Ulixertinib (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC₅₀ of <0.3 nM against ERK2. Ulixertinib (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line .

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Ulixertinib hydrochloride

57 Publications Verification

Cat. No.: HY-15816A

CAS No.: 1956366-10-1

Purity: 99.89%

Synonyms: BVD-523 hydrochloride; VRT752271 hydrochloride

Target:

ERK

Research Areas:

Cancer

Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC₅₀ of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line .

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GDC-0623

11 Cited Publications

Cat. No.: HY-15610

CAS No.: 1168091-68-6

Purity: 98.74%

Synonyms: RG 7421; MEK inhibitor 1

Target:

MEK Apoptosis

Research Areas:

Cancer

GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (K_i=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC₅₀=42 nM) versus A375 (BRAF ^V600E, EC₅₀=7 nM).

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