12710 Results for "

ABCD1 knockout mouse model

" in MedChemExpress (MCE) Product Catalog:

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327

Selisistat

327 Publications Verification

Cat. No.: HY-15452

CAS No.: 49843-98-3

Purity: 99.85%

Synonyms: EX-527

Target:

Sirtuin

Research Areas:

Inflammation/Immunology Cancer

Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC₅₀ of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease ^[1] .

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307

Gemcitabine

307 Cited Publications

Cat. No.: HY-17026

CAS No.: 95058-81-4

Synonyms: LY 188011

Target:

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Autophagy Apoptosis p38 MAPK

Research Areas:

Infection Inflammation/Immunology Cancer

Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, and can modulate autophagy. Gemcitabine induces apoptosis through the activation of p38 MAPK. Gemcitabine demonstrates efficacy in mouse models of pancreatic and breast cancer. Gemcitabine can be used for cancer research, such as pancreatic cancer, non-small cell lung cancer, and breast cancer ^[1] .

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282

Tamoxifen Citrate

282 Cited Publications

Cat. No.: HY-13757

CAS No.: 54965-24-1

Purity: 99.93%

Synonyms: ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate

Target:

Estrogen Receptor/ERR HSP Autophagy Apoptosis

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis. Tamoxifen Citrate can also be used to induce gene knockout in CreER transgenic mice ^[1] .

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282

Tamoxifen

282 Cited Publications

Cat. No.: HY-13757A

CAS No.: 10540-29-1

Purity: 99.78%

Synonyms: ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen

Target:

Estrogen Receptor/ERR HSP Autophagy Apoptosis

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757) ^[1] .

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155

M-CSF Protein, Mouse

155 Cited Publications

Cat. No.: HY-P7085

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: CSF1; Macrophage Colony Stimulating Factor 1; Colony Stimulating Factor 1; Lanimostim; MCSF; MGC31930; Proteoglycan Macrophage Colony-Stimulating Factor; PG-M-CSF; Macrophage Colony-Stimulating Factor 1; CSF-1; M-CSF; CSF1-HERV-LTR71B Fusion Protein; Colo

Species:

Mouse

Source:

E. coli

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128

Palmitic acid

128 Cited Publications

Cat. No.: HY-N0830

CAS No.: 57-10-3

Category:

Cardiovascular Disease Natural Products Neurological Disease Plants Other Families Extract Endogenous metabolite Biological Pesticide Research Agricultural Research Human Gut Microbiota Metabolites Microorganisms Animals Disease Research Fields Cancer

Target:

Environmental Pollutants Endogenous Metabolite HSP

Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model ^[1] .

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128

Palmitic acid sodium

128 Cited Publications

Cat. No.: HY-N0830B

CAS No.: 408-35-5

Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model ^[1] .

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RU.521

91 Cited Publications

Cat. No.: HY-114180

CAS No.: 2262452-06-0

Purity: 99.95%

Synonyms: RU320521

Target:

Cyclic GMP-AMP Synthase

Research Areas:

Metabolic Disease

RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC₅₀ of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) ^[1].

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Neomycin sulfate

82 Cited Publications

Cat. No.: HY-B0470

CAS No.: 1405-10-3

Category:

Disease Research Antibacterial Other Antibiotics Infection Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields

Target:

Environmental Pollutants Antibiotic Phospholipase Bacterial

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer ^[1] .

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TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293, Tag Free)

76 Cited Publications

Cat. No.: HY-P7117

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: TGFB1; Transforming Growth Factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated Peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth Factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth Factor Beta-1;

Species:

Rat Mouse

Source:

HEK293

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Ipatasertib

71 Cited Publications

Cat. No.: HY-15186

CAS No.: 1001264-89-6

Purity: 99.79%

Synonyms: GDC-0068; RG7440

Target:

Organoid Akt Apoptosis

Research Areas:

Cancer

Ipatasertib (GDC-0068) is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC₅₀ values of 5, 18, 8 nM for Akt1/2/3, respectively. Ipatasertib synchronously activates FoxO3a and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models ^[1] .

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666-15

67 Cited Publications

Cat. No.: HY-101120

CAS No.: 1433286-70-4

Purity: 99.74%

Target:

Epigenetic Reader Domain

Research Areas:

Cancer

666-15 is a potent and selective CREB inhibitor with an IC₅₀ of 81 nM. 666-15 suppresses tumor growth in a breast cancer xenograft model ^[1] .

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4-Hydroxytamoxifen

62 Cited Publications

Cat. No.: HY-16950

CAS No.: 68047-06-3

Synonyms: (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; (Z)-Afimoxifene

Target:

Estrogen Receptor/ERR

Research Areas:

Cancer

4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is also the active metabolic form of Tamoxifen (HY-13757A) in vivo and can be used to induce gene knockout in transgenic mice expressing CreER ^[1] .

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IFN-gamma Protein, Mouse

60 Cited Publications

Cat. No.: HY-P7071

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IFNG; IMD69; Interferon Gamma; IFG; IFN-Gamma; IFI; Immune Interferon

Species:

Mouse

Source:

E. coli

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IL-4 Protein, Mouse (CHO)

59 Cited Publications

Cat. No.: HY-P7080

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IL4; B_cell Stimulatory Factor 1; Interleukin 4; B-Cell Stimulatory Factor 1; IL-4; B Cell Growth Factor 1; Lymphocyte Stimulatory Factor 1; Binetrakin; Interleukin-4; Pitrakinra; BCGF-1; MGC79402; BCGF1; BSF-1; BSF1

Species:

Mouse

Source:

CHO

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Zenidolol

52 Cited Publications

Cat. No.: HY-100543

CAS No.: 72795-26-7

Purity: 99.60%

Synonyms: ICI-118551

Target:

Adrenergic Receptor Apoptosis Caspase Bcl-2 Family HIF/HIF Prolyl-Hydroxylase

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Zenidolol (ICI-118551) is a selective β2-adrenergic receptor antagonist with K_i values of Zenidolol for β2, β1 and β3 adrenergic receptors of 0.7, 49.5 and 611 nM, respectively. Zenidolol exerts antitumor effects via inducing apoptosis, inhibiting tumor sphere formation, and downregulating the HIF pathway by blocking β2-AR on tumor cells. Zenidolol exhibits a unique pulmonary vessel-specific vasodilatory effect in mouse models. Zenidolol can be used as an intraocular pressure-lowering agent in ophthalmic disease research ^[1] .

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IL-1 beta Protein, Mouse

52 Cited Publications

Cat. No.: HY-P7073

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IL1B; IL-1B; Interleukin 1 Beta; Multifunctional Fusion Protein; IL1F2; Pro-Interleukin-1-Beta; Interleukin-1 Beta; Preinterleukin 1 Beta; IL1-BETA; Interleukin 1beta; IL-1 Beta; IL1beta; Catabolin; IL-1

Species:

Mouse

Source:

E. coli

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