27

Firsocostat

27 Publications Verification

Cat. No.: HY-16901

CAS No.: 1434635-54-7

Synonyms: ND-630; GS-0976; NDI-010976

Target:

Acetyl-CoA Carboxylase

Research Areas:

Metabolic Disease

Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC₅₀ values of 2.1 and 6.1 nM, respectively.

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14

ND-646

14 Cited Publications

Cat. No.: HY-101842

CAS No.: 1434639-57-2

Purity: 99.13%

Target:

Acetyl-CoA Carboxylase

Research Areas:

Cancer

ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC₅₀s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

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13

CP-640186

13 Cited Publications

Cat. No.: HY-15259

CAS No.: 591778-68-6

Purity: 99.72%

Target:

Acetyl-CoA Carboxylase

Research Areas:

Metabolic Disease

CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation .

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13

CP-640186 hydrochloride

13 Cited Publications

Cat. No.: HY-15259A

CAS No.: 591778-70-0

Purity: 99.90%

Target:

Acetyl-CoA Carboxylase

Research Areas:

Metabolic Disease

CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation .

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12

7ACC2

12 Cited Publications

Cat. No.: HY-D0713

CAS No.: 1472624-85-3

Target:

Monocarboxylate Transporter Mitochondrial Metabolism

Research Areas:

Cancer

7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC₅₀ of 11 nM for inhibition of [ ¹⁴C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux .

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10

7ACC1

10 Cited Publications

Cat. No.: HY-D0067

CAS No.: 50995-74-9

Synonyms: DEAC; Coumarin D 1421; D 1421

Target:

Monocarboxylate Transporter

Research Areas:

Cancer

7ACC1 (DEAC; Coumarin D 1421; D 1421) is a monocarboxylate transporter 1 (MCT-1)/MCT-4 specifc blocker. 7ACC1 attenuates renal cancer cell proliferation, migration, invasion and down-regulates the levels of MCT1/MCT4 expression and extracellular lactate. 7ACC1 is promising for research of cancers .

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9

LDN-212320

9 Cited Publications

Cat. No.: HY-12741

CAS No.: 894002-50-7

Purity: 98.92%

Synonyms: LDN-0212320; OSU-0212320

Target:

EAAT

Research Areas:

Neurological Disease

LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2) activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC ^[1]

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6

PF-05175157

6 Cited Publications

Cat. No.: HY-12942

CAS No.: 1301214-47-0

Purity: 98.46%

Target:

Acetyl-CoA Carboxylase

Research Areas:

Metabolic Disease

PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.

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