27

Donepezil

27 Publications Verification

Cat. No.: HY-14566

CAS No.: 120014-06-4

Purity: 99.82%

Synonyms: E2020 free base

Target:

Cholinesterase (ChE)

Research Areas:

Neurological Disease Cancer

Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

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27

Donepezil Hydrochloride

27 Publications Verification

Cat. No.: HY-B0034

CAS No.: 120011-70-3

Synonyms: E2020

Target:

Cholinesterase (ChE)

Research Areas:

Neurological Disease Cancer

Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

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16

Galanthamine

16 Cited Publications

Cat. No.: HY-76299

CAS No.: 357-70-0

Synonyms: Galantamine

Category:

Alkaloids Other Alkaloids Plants Other Families Extract

Target:

Cholinesterase (ChE) Apoptosis

Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 500 nM.

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16

Galanthamine hydrobromide

16 Cited Publications

Cat. No.: HY-A0009

CAS No.: 1953-04-4

Synonyms: Galantamine hydrobromide

Category:

Alkaloids Other Alkaloids Amaryllidaceae Extract Plants

Target:

Cholinesterase (ChE) nAChR

Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC₅₀ of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α₃β₄, α₄β₂, α₆β₄ nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD) .

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13

α-NETA

13 Cited Publications

Cat. No.: HY-138097

CAS No.: 115066-04-1

Purity: ≥98.0%

Target:

Chemerin Receptor Aldehyde Dehydrogenase (ALDH) Cholinesterase (ChE) Apoptosis

Research Areas:

Cancer

α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC₅₀ of 9 μM. α-NETA is a potent ALDH1A1 (IC₅₀=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC₅₀=84 µM) and acetylcholinesterase (AChE; IC₅₀=300 µM). α-NETA has anti-cancer activity .

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8

Tacrine hydrochloride hydrate

8 Cited Publications

Cat. No.: HY-B2244

CAS No.: 206658-92-6

Target:

Cholinesterase (ChE)

Research Areas:

Neurological Disease

Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC₅₀s of 31 nM and 25.6 nM, respectively.

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8

Tacrine hydrochloride

8 Cited Publications

Cat. No.: HY-B1488

CAS No.: 1684-40-8

Target:

Cholinesterase (ChE) iGluR

Research Areas:

Neurological Disease

Tacrine hydrochloride is a potent brain-penetrant inhibitor of both AChE and BChE, with IC₅₀s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC₅₀ of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease .

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8

Tacrine

8 Cited Publications

Cat. No.: HY-111338

CAS No.: 321-64-2

Purity: 99.91%

Target:

Cholinesterase (ChE)

Research Areas:

Neurological Disease

Tacrine is an effective oral acetylcholine (AChE) inhibitor (IC₅₀ = 109 nM) and also acts as an active substrate for CYP1A2. Tacrine can restore cognitive dysfunction in elderly rats. Tacrine can cause liver toxicity and is used in research related to Alzheimer's disease .

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