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24 Results for "

AD mouse model

" in MedChemExpress (MCE) Product Catalog:

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Zavondemstat

1 Cited Publications

Cat. No.: HY-148807

CAS No.: 1851412-93-5

Purity: 99.12%

Synonyms: QC8222 free base; TACH 101 free base

Target:

Histone Demethylase Apoptosis

Research Areas:

Cancer

Zavondemstat (QC8222 free base; TACH 101 free base) is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

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PBT 1033

1 Cited Publications

Cat. No.: HY-105321

CAS No.: 747408-78-2

Purity: 99.51%

Synonyms: PBT 2

Target:

Bacterial

Research Areas:

Neurological Disease

PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria .

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