55

Bucladesine sodium

55 Publications Verification

Cat. No.: HY-B0764

CAS No.: 16980-89-5

Synonyms: Dibutyryl cAMP sodium; DBcAMP sodium

Target:

PKA Reactive Oxygen Species (ROS) Apoptosis

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Bucladesine (Dibutyryl cAMP; DBcAMP) sodium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

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55

Bucladesine hemicalcium

55 Publications Verification

Cat. No.: HY-B0764A

CAS No.: 938448-87-4

Synonyms: Dibutyryl cAMP hemicalcium; DBcAMP hemicalcium

Target:

PKA Apoptosis Reactive Oxygen Species (ROS)

Research Areas:

Neurological Disease Cancer

Bucladesine (Dibutyryl cAMP; DBcAMP) hemicalcium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

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16

NIK SMI1

16 Cited Publications

Cat. No.: HY-112433

CAS No.: 1660114-31-7

Purity: 99.95%

Target:

NF-κB

Research Areas:

Inflammation/Immunology

NIK SMI1 is a potent, selective NF-κB inducing kinase (NIK) inhibitor, which inhibits NIK-catalyzed hydrolysis of ATP to ADP with IC₅₀ of 0.23±0.17 nM. NIK SMI1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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15

Latrunculin A

15 Cited Publications

Cat. No.: HY-16929

CAS No.: 76343-93-6

Synonyms: LAT-A

Category:

Animals Macrolide Antibiotics Antibiotics Marine natural products Other Diseases Sponge Disease Research Anticancer Disease Research Fields

Target:

Arp2/3 Complex

Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with K_ds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .

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7

MB05032

7 Cited Publications

Cat. No.: HY-16307

CAS No.: 261365-11-1

Target:

FBPase

Research Areas:

Metabolic Disease Cancer

MB05032 is a fructose-1,6-bisphosphatase (FBP1/FBPase) inhibitor with an IC₅₀ value of 16 nM. MB05032 blocks FBP1-mediated glycolysis inhibition in NK cells, restores NK cell glucose uptake, lactate production, degranulation, perforin production, and cytotoxicity against gastric cancer cells. MB05032 elevates ATP/ADP ratios, increases glucose utilization, and enhances insulin secretion in pancreatic β-cells. MB05032 increases neutrophil adhesion, phagocytosis, and mRNA abundance of HKII, ITGA9, CD36 in subclinically hypocalcemic dairy cows. MB05032 inhibits gluconeogenesis in hepatocytes, acts as the active metabolite of prodrug Managlinat dialanetil (MB06322) (HY-14955). MB05032 can be used for the research of gastric cancer, type 2 diabetes, subclinical hypocalcemia, and insulin resistance .

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6

Apyrase

6 Cited Publications

Cat. No.: HY-P2764

CAS No.: 9000-95-7

Target:

NTPDase

Research Areas:

Inflammation/Immunology

Apyrase is an Nucleoside triphosphate diphosphohydrolase (NTPDase). Apyrase can hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP). Apyrase can inhibit Stx2 toxin release of enterohemorrhagic Escherichia coli (EHEC) infection and protect the intestinal barrier function. Apyrase can be used for the research of infection and inflammation, such as hemorrhagic colitis .

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