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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
AG129
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "AG129" in MCE Product Catalog:
Cat. No.: HY-121663
CAS No.: 400863-77-6
Target:
Research Areas:
ST-148 is a novel small molecule compound that has potent inhibitory effects against all four dengue virus serotypes. In the nonlethal AG129 mouse dengue virus infection model, ST-148 significantly reduced viremia and viral load in vital organs and tended to reduce plasma cytokine levels. Compound resistance was associated with the dengue virus capsid (C) gene, and the direct interaction of ST-148 with the C protein was presumed to be achieved through the protein's built-in fluorescence change in the presence of the compound. Therefore, ST-148 appears to interact with the dengue virus C protein and inhibit one or more unique steps of the viral replication cycle.
Cat. No.: HY-189423
Target:
Research Areas:
DENV-IN-16 is a DENV2 E protein binding inhibitor with inhibitory activity against Dengue Virus. DENV-IN-16 blocks the attachment of viral particles to host cells and inhibits DENV attachment/entry at the early stage of the viral life cycle. DENV-IN-16 exhibits antiviral activity against DENV2, DENV1, DENV3, and DENV4, and shows protective efficacy in DENV2-infected AG129 mice. DENV-IN-16 can be used for research on dengue virus infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
