170

Disulfiram

170 Publications Verification

Cat. No.: HY-B0240

CAS No.: 97-77-8

Synonyms: Tetraethylthiuram disulfide; TETD

Target:

Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis

Research Areas:

Metabolic Disease Cancer

Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu ²⁺ increases intracellular ROS levels and induces cuproptosis ^[1] .

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13

α-NETA

13 Cited Publications

Cat. No.: HY-138097

CAS No.: 115066-04-1

Purity: ≥98.0%

Target:

Chemerin Receptor Aldehyde Dehydrogenase (ALDH) Cholinesterase (ChE) Apoptosis

Research Areas:

Cancer

α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC₅₀ of 9 μM. α-NETA is a potent ALDH1A1 (IC₅₀=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC₅₀=84 µM) and acetylcholinesterase (AChE; IC₅₀=300 µM). α-NETA has anti-cancer activity ^[1] .

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8

4-Diethylaminobenzaldehyde

8 Cited Publications

Cat. No.: HY-W016645

CAS No.: 120-21-8

Target:

Aldehyde Dehydrogenase (ALDH)

Research Areas:

Cancer

4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a K_i of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC₅₀= 1.71μM) ^[1] .

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6

NCT-501

6 Cited Publications

Cat. No.: HY-18768

CAS No.: 1802088-50-1

Target:

Aldehyde Dehydrogenase (ALDH) Akt β-catenin Necroptosis

Research Areas:

Cancer

NCT-501 is a reversible, non-competitive, selective, blood-brain barrier-permeable ALDH1A1 inhibitor with an IC₅₀ of 40 nM. NCT-501 inhibits the AKT-β-catenin signaling pathway, induces necroptosis in nasopharyngeal carcinoma cells, suppresses their proliferation and inhibits stem cell spheroid formation. NCT-501 can be used in research related to nasopharyngeal carcinoma, esophageal squamous cell carcinoma and malignant tumors ^[1] .

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4

Win 18446

4 Cited Publications

Cat. No.: HY-W011094

CAS No.: 1477-57-2

Target:

Aldehyde Dehydrogenase (ALDH)

Research Areas:

Endocrinology

Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC₅₀ of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes ^[1] .

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3

CVT-10216

3 Cited Publications

Cat. No.: HY-19801

CAS No.: 1005334-57-5

Target:

Aldehyde Dehydrogenase (ALDH)

Research Areas:

Neurological Disease

CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC₅₀ of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC₅₀ of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects ^[1].

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2

ALDH1A inhibitor 673A

2 Cited Publications

Cat. No.: HY-122912

CAS No.: 109437-62-9

Purity: 99.15%

Synonyms: ALDH1Ai 673A

Target:

Aldehyde Dehydrogenase (ALDH) Mitochondrial Metabolism Necroptosis

Research Areas:

Cancer

ALDH1A inhibitor 673A is an ALDH1A inhibitor with IC₅₀s of 246 nM (ALDH1A1), 230 nM (ALDH1A2), 348 nM (ALDH1A3), respectively. ALDH1A inhibitor 673A has little or no inhibitory effect on other ALDH family members. ALDH1A inhibitor 673A induces necroptotic ovarian cancer stem-like cells (CSCs) death. ALDH1A inhibitor 673A induces DNA double stand breaks in cancer cells. ALDH1A inhibitor 673A can be used for the study of ovarian cancer ^[1] .

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2

MCI-INI-3

2 Cited Publications

Cat. No.: HY-169884

CAS No.: 1011366-31-6

Target:

Aldehyde Dehydrogenase (ALDH)

Research Areas:

Neurological Disease Cancer

MCI-INI-3 is a selective ALDH1A3 inhibitor, with an IC₅₀ of 0.46 μM and a K_i of 0.55 μM against hALDH1A3. MCI-INI-3 inhibits retinoic acid (HY-14649) biosynthesis. MCI-INI-3 can be used in research related to glioblastoma and glioma ^[1] .

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