17

IOX1

17 Publications Verification

Cat. No.: HY-12304

CAS No.: 5852-78-8

Purity: 99.89%

Target:

Histone Demethylase

Research Areas:

Neurological Disease Cancer

IOX1, a chemical probe, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC₅₀ values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively . IOX1 also inhibits ALKBH5 .

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3

DDO-2728

3 Cited Publications

Cat. No.: HY-155489

CAS No.: 3029515-97-4

Purity: 98.55%

Target:

Anaplastic lymphoma kinase (ALK) Apoptosis

Research Areas:

Cancer

DDO-2728 (compound 19) is a selective AlkB homologue 5 (ALKBH5) inhibitor with an IC₅₀ of 2.97 μM. DDO-2728 increases the abundance of N ⁶ methyladenosine (m ⁶A) modifications, inducing cell apoptosis and cycle arrest. DDO-2728 suppresses tumor growth in the MV4 11 xenograft model with favorable safety profile, shows the potential of targeting ALKBH5 in cancer research .

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1

ALKBH5-IN-5

1 Cited Publications

Cat. No.: HY-172158

CAS No.: 140481-05-6

Target:

Anaplastic lymphoma kinase (ALK) Caspase

Research Areas:

Cancer

ALKBH5-IN-5 is a highly selective ALKBH5 (IC₅₀ = 0.62 μM, K_d = 804 nM). ALKBH5-IN-5 disrupts ALKBH5 binding to m ⁶A-RNA and 6mA-DNA substrates. ALKBH5-IN-5 promotes differentiation, induces apoptosis, cause G2-M phase arrest and exerts strong antiproliferative effects in cancer cells. ALKBH5-IN-5 reduces TACC3 and MYC protein levels and increases cleaved caspase-3 levels. ALKBH5-IN-5 exerts antitumor activity in tumor xenograft mice models. ALKBH5-IN-5 can be used for the research of acute myeloid leukemia .

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ALKBH5-IN-3

Cat. No.: HY-165422

CAS No.: 1505579-77-0

Target:

Anaplastic lymphoma kinase (ALK)

Research Areas:

Cancer

ALKBH5-IN-3 is a selective, cell active ALKBH5 inhibitor with an IC₅₀ of 0.021 μM. ALKBH5-IN-3 stabilizes ALKBH5 in HepG2 cells, and increases m ⁶A level in intact cells. ALKBH5-IN-3 can be used as a versatile chemical probe to explore the biological function of ALKBH5. ALKBH5-IN-3 can be used for the research of Cancer .

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Dac590

Cat. No.: HY-174979

CAS No.: 3084407-00-8

Target:

Fat Mass and Obesity-associated Protein (FTO) Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Dac590 is an orally active and selective obesity-associated protein (FTO) inhibitor with an IC₅₀ of 6.06 nM. Dac590 shows highly selective over ALKBH5 and ALKBH3. Dac590 suppresses oncogenic FTO signaling, induces myeloid differentiation, G1-phase cell cycle arrest, and apoptosis in acute myeloid leukemia (AML) cells. Dac590 inhibits xenograft tumor growth and prolongs survival in acute myeloid leukemia mouse models with no observed toxicity. Dac590 can be used for the research of AML .

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W23-1006

Cat. No.: HY-173020

CAS No.: 3035498-92-8

Target:

Anaplastic lymphoma kinase (ALK) Apoptosis

Research Areas:

Cancer

W23-1006 is a selective and covalent ALKBH5 inhibitor. W23-1006 binds to the ALKBH5 C200 residue with an IC₅₀ value of 3.848 μM. W23-1006 shows ~30- and 8-fold stronger inhibitory activity than that against FTO and ALKBH3, respectively. W23-1006 can be used for the study of triple-negative breast cancer (TNBC) .

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ALKBH5-IN-4

Cat. No.: HY-W173146

CAS No.: 37510-29-5

Target:

DNA/RNA Synthesis

Research Areas:

Cancer

ALKBH5-IN-4 (compound 3) is a RNA m6A demethylase ALKBH5 inhibitor with an IC₅₀ of 0.84 μM. ALKBH5-IN-4 shows inhibitory effect on leukemia cells_[1].

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