2929 Results for "

ANCM-RMI interaction

" in MedChemExpress (MCE) Product Catalog:
Products (2929)

2929 Results for "ANCM-RMI interaction" in MCE Product Catalog:

305
Verteporfin
Verteporfin
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305 Publications Verification
Cat. No.: HY-B0146
CAS No.: 129497-78-5
Synonyms: CL 318952
Target:  

YAP Apoptosis Autophagy Photosensitizer

Research Areas:  

Cancer

Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis . Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation .
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266
Angiotensin II human
Angiotensin II human
0 Images
266 Cited Publications
Cat. No.: HY-13948
CAS No.: 4474-91-3
Purity:  99.98%
Synonyms: Angiotensin II; Ang II; DRVYIHPF
Category:  

Natural Products Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:  

Angiotensin Receptor Apoptosis

Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
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266
Angiotensin II human acetate
Angiotensin II human acetate
0 Images
266 Cited Publications
Cat. No.: HY-13948A
CAS No.: 68521-88-0
Purity:  99.62%
Synonyms: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate
Target:  

Angiotensin Receptor Apoptosis

Research Areas:  

Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer

Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
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266
Angiotensin II human TFA
Angiotensin II human TFA
0 Images
266 Cited Publications
Cat. No.: HY-13948B
CAS No.: 2761969-44-0
Purity:  98.84%
Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA
Target:  

Angiotensin Receptor Apoptosis

Research Areas:  

Cardiovascular Disease Metabolic Disease Cancer

Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
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232
Streptavidin Magnetic Beads
Streptavidin Magnetic Beads
0 Images
232 Cited Publications
Cat. No.: HY-K0208

MCE Streptavidin Magnetic Beads provide a fast and convenient method for numerous applications, including purification of proteins and nucleic acids, protein interaction studies, immunoprecipitation, immunoassays, pull-down and cell isolation. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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202
Doxycycline monohydrate
Doxycycline monohydrate
0 Images
202 Cited Publications
Cat. No.: HY-W008923
CAS No.: 17086-28-1
Target:  

MMP Parasite Bacterial Antibiotic Apoptosis Akt PI3K

Research Areas:  

Infection Neurological Disease Inflammation/Immunology Cancer

Doxycycline monohydrate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline monohydrate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline monohydrate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline monohydrate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline monohydrate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline monohydrate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers .
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111
Cytochalasin D
Cytochalasin D
0 Images
111 Cited Publications
Cat. No.: HY-N6682
CAS No.: 22144-77-0
Synonyms: Zygosporin A; NSC 209835
Category:  

Infection Natural Products Microorganisms Disease Research Fields

Target:  

Exosomes Arp2/3 Complex Antibiotic YAP

Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .
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81
Nutlin-3a
Nutlin-3a
0 Images
81 Cited Publications
Cat. No.: HY-10029
CAS No.: 675576-98-4
Purity:  99.00%
Synonyms: Rebemadlin
Target:  

MDM-2/p53 E1/E2/E3 Enzyme Autophagy Apoptosis

Research Areas:  

Cancer

Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas .
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69
ICG-001
ICG-001
0 Images
69 Cited Publications
Cat. No.: HY-14428
CAS No.: 780757-88-2
Purity:  99.86%
Target:  

β-catenin Apoptosis

Research Areas:  

Cancer

ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. ICG-001 works by specifically binding to cyclic AMP response element-binding protein with an IC50 of 3 μM. ICG-001 selectively blocks the β-catenin/CBP interaction without interfering with the β-catenin/p300 interaction.
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69
SKL2001
SKL2001
0 Images
69 Cited Publications
Cat. No.: HY-101085
CAS No.: 909089-13-0
Purity:  99.68%
Target:  

Wnt β-catenin

Research Areas:  

Cancer

SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction .
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64
Heparin sodium salt
Heparin sodium salt
0 Images
64 Cited Publications
Cat. No.: HY-17567A
CAS No.: 9041-08-1
Synonyms: Sodium heparin; Sodium heparinate
Target:  

Exosomes Thrombin Factor Xa Autophagy

Research Areas:  

Cardiovascular Disease Cancer

Heparin sodium salt (Sodium heparin) is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa. Heparin sodium salt significantly inhibits exosome-cell interactions.
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64
Bevacizumab
Bevacizumab
0 Images
64 Cited Publications
Cat. No.: HY-P9906
CAS No.: 216974-75-3
Synonyms: Anti-Human VEGF, Humanized Antibody
Target:  

VEGFR

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

Bevacizumab (Anti-Human VEGF, Humanized Antibody) is a humanized monoclonal antibody against VEGF-A and an angiogenesis inhibitor. Bevacizumab blocks the interaction between VEGF-A and VEGF receptors. Bevacizumab possesses immunomodulatory properties. Bevacizumab can be used in research on metastatic colorectal cancer, metastatic breast cancer, and non-small cell lung cancer .
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64
Bevacizumab (Anti-VEGFA)
Bevacizumab (Anti-VEGFA)
0 Images
64 Cited Publications
Cat. No.: HY-P9906A
CAS No.: 216974-75-3
Target:  

VEGFR

Bevacizumab (Anti-VEGFA) is a humanized monoclonal antibody against VEGF-A and an angiogenesis inhibitor. Bevacizumab (Anti-VEGFA) blocks the interaction between VEGF-A and VEGF receptors. Bevacizumab (Anti-VEGFA) possesses immunomodulatory properties. Bevacizumab (Anti-VEGFA) can be used in research on metastatic colorectal cancer, metastatic breast cancer, and non-small cell lung cancer .
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55
AP20187
AP20187
0 Images
55 Cited Publications
Cat. No.: HY-13992
CAS No.: 195514-80-8
Purity:  99.85%
Synonyms: B/B Homodimerizer
Target:  

FKBP

Research Areas:  

Metabolic Disease

AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
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48
Liothyronine
Liothyronine
0 Images
48 Cited Publications
Cat. No.: HY-A0070A
CAS No.: 6893-02-3
Synonyms: Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3
Category:  

Microorganisms Monophenols Ketones, Aldehydes, Acids Disease markers Endocrine diseases Phenols Endogenous metabolite Disease Research Fields Endocrinology

Target:  

Thyroid Hormone Receptor Endogenous Metabolite

Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with Kis of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .
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43
Emodin
Emodin
0 Images
43 Cited Publications
Cat. No.: HY-14393
CAS No.: 518-82-1
Purity:  99.25%
Synonyms: Frangula emodin
Category:  

Plants Endogenous metabolite Polygonaceae Extract Quinones Human Gut Microbiota Metabolites Microorganisms 500 - Internal Server Error | MedChemExpress

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