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184 Results for "

AP1

" in MedChemExpress (MCE) Product Catalog:

Products (184)

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AP-1

Cat. No.: HY-169481

CAS No.: 3027918-96-0

Research Areas:

Neurological Disease Cancer

AP-1 is a targeted ALK PROTAC degrader. AP-1 effectively degrades various ALK fusion/mutation forms, including degradation of NPM-ALK (DC₅₀ = 4.6 nM) and EML4-ALK (DC₅₀ = 357.6 nM), and exhibits a typical hook effect at high concentrations. AP-1 inhibits phosphorylation of downstream STAT3, downregulates gene expression in the JAK-STAT pathway, and kills ALK-positive tumor cells via activating the caspase-3-dependent apoptosis pathway. AP-1 shows cytotoxicity against a variety of cancer cells and possesses anti-tumor activity. AP-1 can be used in research related to non-small cell lung cancer, neuroblastoma, and anaplastic large cell lymphoma ^[1].

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113

T-5224

113 Publications Verification

Cat. No.: HY-12270

CAS No.: 530141-72-1

Purity: 99.03%

Target:

AP-1 MMP

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription ^[1] .

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SR 11302

29 Cited Publications

Cat. No.: HY-15870

CAS No.: 160162-42-5

Purity: 98.95%

Target:

AP-1

Research Areas:

Inflammation/Immunology Cancer

SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE) ^[1].

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Desipramine hydrochloride

18 Cited Publications

Cat. No.: HY-B1272

CAS No.: 58-28-6

Target:

Adrenergic Receptor ERK JNK p38 MAPK NF-κB AP-1 Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism TNF Receptor

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Desipramine hydrochloride is a first-generation tricyclic antidepressant. Desipramine hydrochloride selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine hydrochloride activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine hydrochloride also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine hydrochloride can be used for the research of hepatocellular cancer, inflammation, and neurological diseases ^[1] .

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