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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
APOA1
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "APOA1" in MCE Product Catalog:
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Cat. No.: HY-P6365
Synonyms: L-4F TFA
APL180 TFA (L-4F TFA) is an Apo-A1 mimetic peptide . APL180 TFA binds oxidized/oxidizable lipids with high affinity and sequesters pro-inflammatory oxidized lipids. APL180 TFA downregulates glycolysis-related genes and HIF-1α expression, and upregulates CD206 and Arginase. APL180 TFA inhibits atherosclerotic lesion progression and platelet aggregation. APL180 TFA attenuates adverse left ventricular remodeling and systolic dysfunction after myocardial infarction. APL180 TFA can be used for research on ovarian cancer [1] .
Target:
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5(Z),11(Z),14(Z)-Eicosatrienoic acid (Sciadonic acid), a polyunsaturated fatty acid sourced from maritime pine seed oil, gymnospermae leaves and seeds, and freshwater gastropods, has been shown to reduce high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1 when included in their diet. In vitro studies indicate that it diminishes cholesterol efflux, and when applied topically in its methyl ester form, it alleviates inflammatory processes, likely by displacing arachidonic acid from phospholipid pools and lowering concentrations of downstream inflammatory mediators such as prostaglandin E2 and leukotrienes.
Cat. No.: HY-RS00829
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APOA1 Human Pre-designed siRNA Set A contains three designed siRNAs for APOA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P991574
CAS No.: 2643310-75-0
Synonyms: REG-101
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Cat. No.: HY-RS17077
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Apoa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apoa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Synonyms: Ethyl pinolenate
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Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.
Cat. No.: HY-RS23521
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Apoa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Apoa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P6365A
CAS No.: 388566-97-0
Synonyms: L-4F
Research Areas:
APL180 (L-4F) is an Apo-A1 mimetic peptide . APL180 binds oxidized/oxidizable lipids with high affinity and sequesters pro-inflammatory oxidized lipids. APL180 downregulates glycolysis-related genes and HIF-1α expression, and upregulates CD206 and Arginase. APL180 inhibits atherosclerotic lesion progression and platelet aggregation. APL180 attenuates adverse left ventricular remodeling and systolic dysfunction after myocardial infarction. APL180 can be used for research on ovarian cancer [1] .
Cat. No.: HY-P10453
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Cat. No.: HY-121698
CAS No.: 1373353-95-7
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GW694481 is an ApoA1 upregulator with IC50 values of 2.1 μM for CYP2C9 inhibition and 17.0 μM for CYP3A4 inhibition. GW694481 upregulates ApoA1 expression in human hepatic cells.GW694481 can be used for the research of atherosclerosis [1].
Cat. No.: HY-P706290
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ¹⁵N-Recombinant Human Apolipoprotein A1; ¹⁵N-rhAPOA-I; APOA1; APOA1 Protein; Apolipoprotein A1; Apo(A); Apolipoprotein A-I; HPALP2; Apo-AI; AMYLD3; Epididymis Secretory Sperm Binding Protein; APOA-I
Species:
Human
Source:
HEK293
Cat. No.: HY-P75503A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: APOA1; APOA1 Protein; Apolipoprotein A1; Apo(A); Apolipoprotein A-I; HPALP2; Apo-AI; AMYLD3; Epididymis Secretory Sperm Binding Protein; APOA-I
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P76155
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NAXE; YjeF N-Terminal Domain-Containing Protein 1; Prev. APOA1BP; MGC119145; AIBP; MGC119144; NAD(P)H-Hydrate Epimerase; MGC119143; YJEFN1; YjeF_N1; Apolipoprotein A-I-Binding Protein; Apolipoprotein A-I Binding Protein; AI-BP; PEBEL; NAD(P)HX Epimerase;
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
