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83 Results for "

APP Inhibitor

" in MedChemExpress (MCE) Product Catalog:

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163

Mirdametinib

163 Publications Verification

Cat. No.: HY-10254

CAS No.: 391210-10-9

Purity: 99.95%

Synonyms: PD0325901; PD325901

Target:

MEK Autophagy Apoptosis

Research Areas:

Cancer

Mirdametinib (PD0325901) is an orally active, selective and non-ATP-competitive MEK inhibitor with an IC₅₀ of 0.33 nM. Mirdametinib exhibits a K_i ^app of 1 nM against activated MEK1 and MEK2. Mirdametinib suppresses the expression of p-ERK1/2 and induces apoptosis. Mirdametinib has anti-cancer activity for a broad spectrum of human tumor xenografts .

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August 31

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Takinib

33 Cited Publications

Cat. No.: HY-103490

CAS No.: 1111556-37-6

Purity: 99.41%

Synonyms: EDHS-206

Target:

MAP3K Apoptosis

Research Areas:

Infection Inflammation/Immunology Cancer

Takinib (EDHS-206) is an orally active and selective TAK1 inhibitor (IC₅₀=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively. Takinib is an inhibitor of autophosphorylated TAK1 that non-competitively binds within the ATP binding pocket. Takinib induces apoptosis following TNFα stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is also a P. falciparum protein kinase 9 (PfPK9) inhibitor (K_D(app) of 0.46 μM) .

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