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84 Results for "

AQP

" in MedChemExpress (MCE) Product Catalog:

Products (84)

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TGN-020

26 Publications Verification

Cat. No.: HY-W008574

CAS No.: 51987-99-6

Target:

PROTAC Linkers

Research Areas:

Inflammation/Immunology Cancer

TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .

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TGN-020 sodium

26 Publications Verification

Cat. No.: HY-W008574A

CAS No.: 1313731-99-5

Target:

PROTAC Linkers

Research Areas:

Inflammation/Immunology Cancer

TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .

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DFP00173

8 Cited Publications

Cat. No.: HY-126073

CAS No.: 672286-03-2

Purity: 99.46%

Target:

Aquaporin

Research Areas:

Inflammation/Immunology Cancer

DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC₅₀ of ～0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9 .

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Bisacodyl

2 Cited Publications

Cat. No.: HY-B0557

CAS No.: 603-50-9

Target:

Dopamine Transporter Opioid Receptor

Research Areas:

Metabolic Disease Cancer

Bisacodyl is a stimulant laxative agent that works directly on the colon to produce a bowel movement. Bisacodyl increases the secretion of PGE₂ by direct activation of colon macrophages. PGE₂ acts as a paracrine factor and decreases the expression of AQP3 in the colon, which inhibits water transfer from the luminal to the vascular side and leads to a laxative effect .

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Z433927330

2 Cited Publications

Cat. No.: HY-126074

CAS No.: 1005883-72-6

Purity: 98.11%

Target:

Aquaporin

Research Areas:

Others

Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC₅₀s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively .

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