358 Results for "

AR Inhibitor

" in MedChemExpress (MCE) Product Catalog:
Products (358)

358 Results for "AR Inhibitor" in MCE Product Catalog:

55
Propranolol hydrochloride
Propranolol hydrochloride
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55 Publications Verification
Cat. No.: HY-B0573
CAS No.: 318-98-9
Category:  

Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields Endocrinology

Target:  

Adrenergic Receptor Bacterial

Propranolol hydrochloride is a nonselective and BBB-permeableβ-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [ 3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .
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55
Propranolol
Propranolol
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55 Publications Verification
Cat. No.: HY-B0573B
CAS No.: 525-66-6
Category:  

Cardiovascular Disease Alkaloids Natural Products Neurological Disease Other Alkaloids Plants Aconitum carmichaeli Debx. Extract Disease Research Fields Ranunculaceae Extract

Target:  

Adrenergic Receptor Bacterial

Propranolol is a nonselective and BBB-permeable β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively . Propranolol inhibits [ 3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM . Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .
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54
AR-C155858
AR-C155858
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54 Cited Publications
Cat. No.: HY-13248
CAS No.: 496791-37-8
Purity:  99.62%
Target:  

Monocarboxylate Transporter

Research Areas:  

Others

AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with Kis of 2.3 nM and 10 nM, respectively.
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52
Zenidolol
Zenidolol
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52 Cited Publications
Cat. No.: HY-100543
CAS No.: 72795-26-7
Purity:  99.60%
Synonyms: ICI-118551
Target:  

Adrenergic Receptor Apoptosis Caspase Bcl-2 Family HIF/HIF Prolyl-Hydroxylase

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Zenidolol (ICI-118551) is a selective β2-adrenergic receptor antagonist with Ki values of Zenidolol for β2, β1 and β3 adrenergic receptors of 0.7, 49.5 and 611 nM, respectively. Zenidolol exerts antitumor effects via inducing apoptosis, inhibiting tumor sphere formation, and downregulating the HIF pathway by blocking β2-AR on tumor cells. Zenidolol exhibits a unique pulmonary vessel-specific vasodilatory effect in mouse models. Zenidolol can be used as an intraocular pressure-lowering agent in ophthalmic disease research .
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30
ARV-771
ARV-771
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30 Cited Publications
Cat. No.: HY-100972
CAS No.: 1949837-12-0
Purity:  98.87%
Target:  

PROTACs Epigenetic Reader Domain Apoptosis Ferroptosis c-Myc Androgen Receptor

Research Areas:  

Cancer

ARV-771 is a BET PROTAC degrader, with Kd values of 34, 4.7, 8.3, 7.6, 9.6 and 7.6 nM against BRD2 (1), BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1) and BRD4 (2) , respectively. ARV-771 inhibits the transcription of AR/AR-v7 and its downstream target genes. By degrading BRD4 protein, ARV-771 enhances the sensitivity of prostate cancer cells to ferroptosis, suppresses cancer cell viability, and induces apoptosis. ARV-771 downregulates the levels of BRD4, c-MYC and AR-V7 in tumor tissues and inhibits tumor tissue growth. ARV-771 can be used in prostate cancer-related research .
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21
AR-A014418
AR-A014418
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21 Cited Publications
Cat. No.: HY-10512
CAS No.: 487021-52-3
Purity:  99.21%
Synonyms: AR 0133418; GSK 3β Inhibitor VIII; AR 014418
Target:  

GSK-3

Research Areas:  

Metabolic Disease Cancer

AR-A014418 is a potent, selective and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM) .
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14
Inobrodib
Inobrodib
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14 Cited Publications
Cat. No.: HY-111784
CAS No.: 2222941-37-7
Purity:  99.94%
Synonyms: CCS1477
Target:  

Ligands for Target Protein for PROTAC Epigenetic Reader Domain Histone Acetyltransferase

Research Areas:  

Cancer

Inobrodib (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. Inobrodib binds to p300 and CBP with Kd values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a Kd of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression .
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13
Darolutamide
Darolutamide
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13 Cited Publications
Cat. No.: HY-16985
CAS No.: 1297538-32-9
Synonyms: ODM-201; BAY-1841788
Target:  

Androgen Receptor

Research Areas:  

Cancer

Darolutamide (ODM-201) is an orally active competitive androgen receptor (AR) antagonist. Darolutamide has a Ki of 11 nM for rat wild-type AR (wtAR) and IC50 of 26 nM for human wild-type AR (hAR)-mediated transcriptional activation . Darolutamide inhibits testosterone-induced AR nuclear translocation and transcriptional activation . Darolutamide exerts selective effects on AR-positive cells by inhibiting AR-dependent signaling pathways, and its active metabolite retains full antagonistic activity against AR mutants . Darolutamide can be used for the research of prostate cancer, including androgen receptor-dependent prostate cancer .
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12
Higenamine
Higenamine
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12 Cited Publications
Cat. No.: HY-N2037
CAS No.: 5843-65-2
Synonyms: Norcoclaurine; Demethyl-Coclaurine
Category:  

Alkaloids Phenols Polyphenols Plants Aconitum carmichaeli Debx. Extract Disease Research Fields Isoquinoline Alkaloids Endocrinology Ranunculaceae Extract

Target:  

MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis

Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
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12
Corylin
Corylin
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12 Cited Publications
Cat. No.: HY-N0236
CAS No.: 53947-92-5
Category:  

Infection Flavonoids Monophenols Phenols 500 - Internal Server Error | MedChemExpress

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