1 Result for "

ASFV g5Rp

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "ASFV g5Rp" in MCE Product Catalog:

1
9''-Methyl salvianolate B
9''-Methyl salvianolate B
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1 Cited Publications
Cat. No.: HY-N2397
CAS No.: 1167424-31-8
Synonyms: MSB
Category:  

Plant Simple Phenylpropanols Metabolic Disease Phenols Polyphenols Salvia miltiorrhiza Bunge Extract Phenylpropanoids Disease Research Fields Labiatae Extract

Target:  

DNA/RNA Synthesis PPAR NF-κB Autophagy

9''-Methyl salvianolate B (MSB) is a blood-brain barrier-permeable inhibitor with high affinity for g5Rp, with a Kd value of 117 nM against African swine fever virus (ASFV) g5Rp. 9''-Methyl salvianolate B also acts as a ZBP1 inhibitor. It exhibits strong binding affinity to key proteins in the PPARγ/NF-κB pathway. 9''-Methyl salvianolate B blocks the interaction between ASFV g5Rp and host proteins eIF5A or RPS15. It restores hypusination modification of eIF5A, promotes autophagy (Autophagy), and inhibits ASFV replication. 9''-Methyl salvianolate B effectively disrupts ZBP1-mediated PANoptosome assembly. It effectively alleviates myocardial ischemia/reperfusion injury. 9''-Methyl salvianolate B can be used in studies related to African swine fever .
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