Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
ATCC 21838
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "ATCC 21838" in MCE Product Catalog:
32
Category:
Umbelliferae/Apiaceae Extract Plant Neurological Disease Ketones, Aldehydes, Acids Disease Research Fields Endocrinology Cancer Angelica sinensis (Oliv.) Diels Extract
Target:
4
4 Cited Publications
Cat. No.: HY-19759
CAS No.: 1001908-89-9
SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM . SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels .
1
1 Cited Publications
Cat. No.: HY-17501A
CAS No.: 81732-46-9
Synonyms: (±)-Bambuterol hydrochloride; KWD-2183 hydrochloride
Target:
Research Areas:
Bambuterol hydrochloride ((±)-Bambuterol hydrochloride; KWD-2183 hydrochloride) is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a proagent of terbutaline.
Cat. No.: HY-171767
CAS No.: 3038446-94-2
Synonyms: JB325
Target:
Research Areas:
SK2188 (JB325) is a selective AURKA PROTAC degrader with a DC50 of 3.9 nM. SK2188 recruits CRBN E3 ubiquitin ligase to target and degrade AURKA, abrogating both its catalytic and non-kinase functions, which leads to the destabilization and degradation of the oncogenic protein MYCN, ultimately inducing replication stress, DNA damage and apoptosis. SK2188 is applicable to research related to neuroblastoma .
Synonyms: EYE001; NX1838
Target:
Research Areas:
Pegaptanib sodium is an RNA aptamer with polyethylene glycol modifications, which is directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .
Cat. No.: HY-P991681
CAS No.: 3051701-97-1
Synonyms: ASP-2138
Cat. No.: HY-169138
CAS No.: 140841-32-3
Target:
Research Areas:
ZD 2138 is a selective 5-lipoxygenase (5-lipoxygenase) inhibitor with an IC50 of 20-50 nM. ZD 2138 inhibits cytokine-induced rolling and adhesion of leukocytes on bovine aortic endothelial cells. ZD 2138 is applicable to research related to inflammatory diseases such as acute asthma .
Cat. No.: HY-164906
CAS No.: 2488892-07-3
TMX-2138 is a CDK PROTAC degrader, with IC50 values against different targets as follows: CDK1 (IC50 = 8.7 nM), CDK2 (IC50 = 10.9 nM), CDK5 (IC50 = 7.0 nM), CDK4 (IC50 = 901.0 nM), CDK6 (IC50 = 465.0 nM), CDK7 (IC50 = 286.0 nM), and CDK9 (IC50 = 25.7 nM). TMX-2138 promotes the ubiquitination of CDK and induces its degradation via the proteasomal pathway. TMX-2138 can be used in ovarian cancer research .
Cat. No.: HY-17501S
CAS No.: 1794810-59-5
Synonyms: (±)-Bambuterol-d9 hydrochloride; KWD-2183-d9 hydrochloride
Cat. No.: HY-17501
CAS No.: 81732-65-2
Synonyms: (±)-Bambuterol; KWD-2183
Category:
Target:
Target:
Research Areas:
Deschlorohaloperidol (compound 8h) is an analogue of Haloperidol (HY-14538). Haloperidol is a dopamine D2 receptor (D2R) antagonist for schizophrenia .
Cat. No.: HY-17501AR
CAS No.: 81732-46-9
Synonyms: (±)-Bambuterol hydrochloride (Standard); KWD-2183 hydrochloride (Standard)
Research Areas:
Bambuterol hydrochloride (Standard) is the analytical standard of Bambuterol hydrochloride. This product is intended for research and analytical applications. Bambuterol hydrochloride ((±)-Bambuterol hydrochloride; KWD-2183 hydrochloride) is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a proagent of terbutaline.
Cat. No.: HY-P4801
CAS No.: 160489-86-1
Synonyms: Human PACAP(28-38)
Target:
Research Areas:
Cat. No.: HY-116219
CAS No.: 16386-65-5
Target:
Research Areas:
WB2838 is a non-steroidal androgen-receptor antagonist (IC50: 0.8 μM for partially purified rat prostate cytosol receptor). WB2838 exhibits anti-cancer activity against androgen-responsive breast cancer. WB2838 also shows the inhibitory activity against the growth of the ventral prostate induced by Testosterone propionate .
Cat. No.: HY-120916
CAS No.: 146440-20-2
Cat. No.: HY-29468
CAS No.: 133914-85-9
Target:
Research Areas:
LCB-2183 is an orally active antiallergic agent. LCB-2183 can inhibit tracheal hyperreactivity and pulmonary inflammation in mouse airways .
Cat. No.: HY-R02838A
mmu-miR-2183 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
Cat. No.: HY-RI02838
mmu-miR-2183 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
Cat. No.: HY-RI02838A
mmu-miR-2183 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
